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Segment reporting | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Segment reporting | Segment reporting The Company has one reportable segment. The Company’s Chief Operating Decision Maker (the “CODM”), its Chief Executive Officer, manages the Company’s operations on a consolidated basis for the purposes of allocating resources, making operating decisions and evaluating performance. When evaluating the Company’s financial performance, the CODM regularly reviews total expenses by expense category and the CODM makes decisions using this information on a consolidated basis. There are no other measures of profitability used by the CODM, other than those disclosed in these condensed consolidated financial statements. The table below is a summary of the significant segment expenses (in thousands) provided to the Company’s CODM on a regular basis:
|  | Three Months Ended September 30, | Nine Months Ended September 30,
|  | 2025 |  | 2024 | 2025 |  | 2024
Drug creation programs and platform (1) |  | $ | 5,669 |  |  | $ | 4,144 |  | $ | 14,963 |  |  | $ | 11,635 |
External preclinical and clinical development (2) |  | 3,606 |  |  | 2,852 |  | 11,660 |  |  | 5,178 |
Personnel (3) |  | 10,488 |  |  | 9,813 |  | 30,638 |  |  | 29,137 |
Stock-based compensation |  | 4,396 |  |  | 5,508 |  | 14,093 |  |  | 14,401 |
General & administrative |  | 3,531 |  |  | 3,799 |  | 11,158 |  |  | 11,352 |
Asset and goodwill impairment |  | — |  |  | 1,125 |  | — |  |  | 1,125 |
Depreciation and amortization |  | 2,842 |  |  | 3,355 |  | 8,914 |  |  | 10,155 |
Total operating expenses |  | $ | 30,532 |  |  | $ | 30,596 |  | $ | 91,426 |  |  | $ | 82,983 |
(1) “Drug creation programs and platform” consists of research and development costs incurred related to the Company’s internally developed programs and drug creation partnership programs for activities prior to the nomination of a development candidate and the continued development of the Company’s Integrated Drug Creation platform. (2) “External preclinical and clinical development” expense consists of external costs incurred following the Company’s nomination of a development candidate, including all subsequent contract research services, contract manufacturing, consulting fees, and other external costs related to preclinical and clinical development. (3) “Personnel” expense consists of all employee wages, taxes, benefits, other employee related costs.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 21 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-21 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name 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