<SEC-DOCUMENT>0001752724-19-163927.txt : 20191115
<SEC-HEADER>0001752724-19-163927.hdr.sgml : 20191115
<ACCEPTANCE-DATETIME>20191115132727
ACCESSION NUMBER:		0001752724-19-163927
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20190930
FILED AS OF DATE:		20191115
PERIOD START:           	20190930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA LIFE SCIENCES INVESTORS
		CENTRAL INDEX KEY:			0000884121
		IRS NUMBER:				043147016
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-06565
		FILM NUMBER:		191223465

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q LIFE SCIENCES INVESTORS
		DATE OF NAME CHANGE:	19920929
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <invstOrSec>
        <name>Jazz Pharmaceuticals PLC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Adaptimmune Therapeutics PLC</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Illumina Inc</name>
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        <name>THEROX MILESTONE INTEREST</name>
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        <name>Cardiokinetix Inc</name>
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        <name>Avadel Pharmaceuticals PLC</name>
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        <name>Illuminoss Inc.</name>
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        <name>United Therapeutics Corp</name>
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        <name>Bluebird Bio Inc</name>
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        <name>Ligand Pharmaceuticals Inc</name>
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        <name>Argenx SE</name>
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        <name>Amgen Inc</name>
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        <name>Cardiokinetix Inc</name>
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        <name>Verona Pharma PLC</name>
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        <lei>52990044IHUOUMETT163</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Threshold Pharmaceuticals Inc</name>
        <lei>529900VZKP6N0B8U5F61</lei>
        <title>Molecular Templates Inc</title>
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          <isin value="US6085501095"/>
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        <balance>62194.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Sage Therapeutics Inc</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>Sage Therapeutics Inc</title>
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          <isin value="US78667J1088"/>
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        <balance>30816.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Cellectis SA</name>
        <lei>5493000KKX5VQ37Q2W83</lei>
        <title>Cellectis SA</title>
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          <isin value="US15117K1034"/>
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        <balance>47437.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>FR</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Portola Pharmaceuticals Inc</name>
        <lei>549300BM3O4O0CNBGJ64</lei>
        <title>Portola Pharmaceuticals Inc</title>
        <cusip>737010108</cusip>
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          <isin value="US7370101088"/>
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        <balance>44891.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
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          <isin value="US45168D1046"/>
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        <balance>8329.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Cardiokinetix Inc</name>
        <lei>N/A</lei>
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          <other otherDesc="Internal Identifier" value="ACI00DHT5"/>
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        <balance>142574.00000000</balance>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. WARRANTS WARRANTS</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS WARRANTS</title>
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          <other otherDesc="Internal Identifier" value="965DWXII0"/>
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        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
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            <putOrCall>Call</putOrCall>
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                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
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      <invstOrSec>
        <name>Immunomedics Inc</name>
        <lei>5493007ZU7DDO8PSIM59</lei>
        <title>Immunomedics Inc</title>
        <cusip>452907108</cusip>
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          <isin value="US4529071080"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Novocure Ltd</name>
        <lei>213800YPP55UMHWA4826</lei>
        <title>Novocure Ltd</title>
        <cusip>000000000</cusip>
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          <isin value="JE00BYSS4X48"/>
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        <balance>37825.00000000</balance>
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        <invCountry>JE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARCA Biopharma, Inc.</name>
        <lei>529900TG7O4ESUDMGI54</lei>
        <title>ARCA Biopharma, Inc.</title>
        <cusip>00211Y506</cusip>
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          <isin value="US00211Y5069"/>
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        <balance>36068.00000000</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Afferent Milestone Interest</name>
        <lei>N/A</lei>
        <title>AFFERENT MILESTONE INTEREST COMMON STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="930LUG902"/>
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        <balance>11232.03000000</balance>
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        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Verona Pharma PLC</name>
        <lei>213800EVI6O6J3TIAL06</lei>
        <title>Verona Pharma PLC Wts Put Exp 27Apr22</title>
        <cusip>000000000</cusip>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Arena Pharmaceuticals Inc</name>
        <lei>529900CVGQMPJ3A3NI85</lei>
        <title>Arena Pharmaceuticals Inc</title>
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        <name>TRILLIUM THERAPEUTICS INC NON</name>
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        <invCountry>CA</invCountry>
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      <invstOrSec>
        <name>Targegen Milestone Interest</name>
        <lei>N/A</lei>
        <title>TARGEGEN MILESTONE INTEREST PREFERRED STOCK</title>
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          <other otherDesc="Internal Identifier" value="ACI006B74"/>
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      <invstOrSec>
        <name>Illuminoss Inc.</name>
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        <title>Illuminoss Inc. Warrants Call Exp 11Jan28</title>
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        <name>Illuminoss Inc.</name>
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        <name>Bio-Techne Corp</name>
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        <title>Bio-Techne Corp</title>
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        <name>Illuminoss Inc.</name>
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        <title>ILLUMINOSS INC CONVERTIBLE PROMISSORY NOTE</title>
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        <name>Insmed Inc</name>
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        <name>Celgene Corp</name>
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        <name>uniQure NV</name>
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        <name>Biogen Inc</name>
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        <name>Neurocrine Biosciences Inc</name>
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        <name>Tetraphase Pharmaceuticals Inc</name>
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        <name>Ionis Pharmaceuticals Inc</name>
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        <name>Bellicum Pharmaceuticals Inc</name>
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        <name>Magenta Therapeutics Inc</name>
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        <name>ACADIA Pharmaceuticals Inc</name>
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        <name>OCULIS SA</name>
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        <name>Global Blood Therapeutics Inc</name>
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        <name>Alkermes PLC</name>
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        <name>CRISPR Therapeutics AG</name>
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        <name>AC Immune SA</name>
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        <name>WaVe Life Sciences Ltd</name>
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        <name>PRA Health Sciences Inc</name>
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        <name>SPDR S&amp;P Biotech ETF</name>
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        <name>Zogenix Inc</name>
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        <name>Regeneron Pharmaceuticals Inc</name>
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        <name>Ovid therapeutics Inc</name>
        <lei>549300H36NUI4L6U8F17</lei>
        <title>Ovid therapeutics Inc</title>
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        <name>Endo International PLC</name>
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        <name>Cercacor Laboratories Inc</name>
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        <name>Decipher Biosciences, Inc.</name>
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        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
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      <invstOrSec>
        <name>Illuminoss Inc.</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>AQUAMED TECHNOLOGIES INC COMMON STOCK</name>
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      <invstOrSec>
        <name>Trillium Therapeutics Inc</name>
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        <name>Adynxx Inc</name>
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        <name>Pacific Biosciences of California Inc</name>
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        <name>Illuminoss Inc.</name>
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        <name>Verona Pharma PLC</name>
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        <name>FIXED INC CLEARING CORP.REPO</name>
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        <name>Pieris Pharmaceuticals Warrant Series A</name>
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        <title>Pieris Pharmaceuticals Warrant Series A</title>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
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            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
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              <otherRefInst>
                <issuerName>Pieris Pharmaceuticals Inc</issuerName>
                <issueTitle>Pieris Pharmaceuticals Inc</issueTitle>
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                  <cusip value="720795103"/>
                  <isin value="US7207951036"/>
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              </otherRefInst>
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            <shareNo>1.00000000</shareNo>
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            <exercisePriceCurCd>USD</exercisePriceCurCd>
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            <delta>XXXX</delta>
            <unrealizedAppr>39428.18000000</unrealizedAppr>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Milestone Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Milestone Pharmaceuticals Inc</title>
        <cusip>59935V107</cusip>
        <identifiers>
          <isin value="CA59935V1076"/>
        </identifiers>
        <balance>14082.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>243618.60000000</valUSD>
        <pctVal>0.063518164330</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Decipher Biosciences, Inc.</name>
        <lei>N/A</lei>
        <title>DECIPHER BIOSCIENCES, INC. SERIES II CONVERTIBLE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964DAK902"/>
        </identifiers>
        <balance>398613.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>556862.36000000</valUSD>
        <pctVal>0.145189549944</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sutro Biopharma Inc</name>
        <lei>5493005U6P15VD25P851</lei>
        <title>Sutro Biopharma Inc</title>
        <cusip>869367102</cusip>
        <identifiers>
          <isin value="US8693671021"/>
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        <balance>193471.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1758651.39000000</valUSD>
        <pctVal>0.458529471848</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>Rocket Pharmaceuticals Inc</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
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        <balance>63455.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>739250.75000000</valUSD>
        <pctVal>0.192743290619</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exelixis Inc</name>
        <lei>N/A</lei>
        <title>Exelixis Inc</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
        </identifiers>
        <balance>95998.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1697724.63000000</valUSD>
        <pctVal>0.442644166072</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acceleron Pharma Inc</name>
        <lei>529900TQRID2UY164805</lei>
        <title>Acceleron Pharma Inc</title>
        <cusip>00434H108</cusip>
        <identifiers>
          <isin value="US00434H1086"/>
        </identifiers>
        <balance>30541.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1206674.91000000</valUSD>
        <pctVal>0.314613807103</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>iShares Nasdaq Biotechnology ETF</name>
        <lei>549300S7IVD88MPK0066</lei>
        <title>iShares Nasdaq Biotechnology ETF</title>
        <cusip>464287556</cusip>
        <identifiers>
          <isin value="US4642875565"/>
        </identifiers>
        <balance>18914.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1881943.00000000</valUSD>
        <pctVal>0.490675033577</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>549300B66JN3W3J8GH73</lei>
        <title>Ascendis Pharma A/S</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
        </identifiers>
        <balance>30582.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2945658.24000000</valUSD>
        <pctVal>0.768015267104</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Intercept Pharmaceuticals Inc</title>
        <cusip>45845P108</cusip>
        <identifiers>
          <isin value="US45845P1084"/>
        </identifiers>
        <balance>13082.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>868121.52000000</valUSD>
        <pctVal>0.226343494981</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Editas Medicine Inc</name>
        <lei>5299000AON4Q9NT2JE42</lei>
        <title>Editas Medicine Inc</title>
        <cusip>28106W103</cusip>
        <identifiers>
          <isin value="US28106W1036"/>
        </identifiers>
        <balance>49733.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1130928.42000000</valUSD>
        <pctVal>0.294864584345</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quotient Ltd</name>
        <lei>549300BOTHGGT8D81659</lei>
        <title>Quotient Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="JE00BLG2ZQ72"/>
        </identifiers>
        <balance>121721.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>945772.17000000</valUSD>
        <pctVal>0.246589185363</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINOSS INC. WARRANTS WARRANTS</name>
        <lei>N/A</lei>
        <title>ILLUMINOSS INC. WARRANTS WARRANTS</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="965HDUII8"/>
        </identifiers>
        <balance>53690.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2029-09-27</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>0.00000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Inogen Inc</name>
        <lei>549300J8WJIVTOJ8IH97</lei>
        <title>Inogen Inc</title>
        <cusip>45780L104</cusip>
        <identifiers>
          <isin value="US45780L1044"/>
        </identifiers>
        <balance>8162.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>391041.42000000</valUSD>
        <pctVal>0.101955405604</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAINIER THERAPEUTICS, INC. CONVERTIBLE PROMISSORY NOTE</name>
        <lei>N/A</lei>
        <title>RAINIER THERAPEUTICS, INC. CONVERTIBLE PROMISSORY NOTE</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="964TJFII0"/>
        </identifiers>
        <balance>189672.50000000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>189672.50000000</valUSD>
        <pctVal>0.049452911329</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <debtSec>
          <maturityDt>2020-03-31</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>8.00000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cardiokinetix Inc</name>
        <lei>N/A</lei>
        <title>Cardiokinetix Inc Warrants</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="924ZCQ907"/>
        </identifiers>
        <balance>8821.69000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>CADIOKINETIX SERIES C</issuerName>
                <issueTitle>CADIOKINETIX SERIES C</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="141998963"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>2.85000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2024-08-15</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-141.82000000</unrealizedAppr>
          </optionSwaptionWarrantDeriv>
        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="931ELZII6 -ILLUMINOSS INC. CONVERTIBLEPROMISSORY NOTE  -  Conversion of this note is dependent upon unknown future events therefore underlying reference instrument cannot be determined at this time.                " noteItem="C.11.c.iii.3"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2019-10-23</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA LIFE SCIENCES INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
