<SEC-DOCUMENT>0001752724-20-108408.txt : 20200528
<SEC-HEADER>0001752724-20-108408.hdr.sgml : 20200528
<ACCEPTANCE-DATETIME>20200528165027
ACCESSION NUMBER:		0001752724-20-108408
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20200331
FILED AS OF DATE:		20200528
PERIOD START:           	20200930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA LIFE SCIENCES INVESTORS
		CENTRAL INDEX KEY:			0000884121
		IRS NUMBER:				043147016
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-06565
		FILM NUMBER:		20921902

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q LIFE SCIENCES INVESTORS
		DATE OF NAME CHANGE:	19920929
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Bellicum Pharmaceuticals Inc</name>
        <lei>529900HBXNLX2TBQZQ65</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Illumina Inc</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina Inc</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Epizyme Inc</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Illuminoss Inc.</name>
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        <fairValLevel>3</fairValLevel>
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        <name>Afferent Milestone Interest</name>
        <lei>N/A</lei>
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        <cusip>000000000</cusip>
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          <other otherDesc="Internal Identifier" value="930LUG902"/>
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        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Rainier Therapeutics Series A PREFERRED STOCK</name>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>PRA Health Sciences Inc</name>
        <lei>549300R1HR1VWWHIAK47</lei>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>MyoKardia Inc</name>
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        <title>MyoKardia Inc</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Revance Therapeutics Inc</name>
        <lei>549300N33TFDZHS81H11</lei>
        <title>Revance Therapeutics Inc</title>
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          <isin value="US7613301099"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Seattle Genetics Inc</name>
        <lei>N/A</lei>
        <title>Seattle Genetics Inc</title>
        <cusip>812578102</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Editas Medicine Inc</name>
        <lei>5299000AON4Q9NT2JE42</lei>
        <title>Editas Medicine Inc</title>
        <cusip>28106W103</cusip>
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          <isin value="US28106W1036"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Cymabay Therapeutics Inc</name>
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        <title>Cymabay Therapeutics Inc</title>
        <cusip>23257D103</cusip>
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          <isin value="US23257D1037"/>
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        <balance>32636.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Atreca Inc</name>
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        <title>Atreca Inc</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>Halozyme Therapeutics Inc</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Amgen Inc</name>
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        <title>Amgen Inc</title>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BeiGene Ltd</name>
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        <title>BeiGene Ltd</title>
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        <assetCat>EC</assetCat>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Ultragenyx Pharmaceutical Inc</name>
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        <title>Ultragenyx Pharmaceutical Inc</title>
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        <name>Galera Therapeutics Inc</name>
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        <name>Turning Point Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Ligand Pharmaceuticals Inc</name>
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        <title>Ligand Pharmaceuticals Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Medpace Holdings Inc</name>
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        <title>Medpace Holdings Inc</title>
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        <assetCat>EC</assetCat>
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        <name>Aerie Pharmaceuticals Inc</name>
        <lei>529900SFXHDHUO324R09</lei>
        <title>Aerie Pharmaceuticals Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Momenta Pharmaceuticals Inc</name>
        <lei>529900BB2VMRCT4YQ588</lei>
        <title>Momenta Pharmaceuticals Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Iovance Biotherapeutics Inc</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>Iovance Biotherapeutics Inc</title>
        <cusip>462260100</cusip>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <name>THERACHON MILESTONE INTEREST</name>
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        <name>United Therapeutics Corp</name>
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        <name>Aurinia Pharmaceuticals Inc</name>
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        <name>ARCA biopharma Inc</name>
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        <name>Bio-Techne Corp</name>
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        <name>FibroGen Inc</name>
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        <name>Exact Sciences Corp</name>
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        <name>OCULIS SA</name>
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        <name>Illuminoss Inc.</name>
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        <name>Exelixis Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
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        <name>Illuminoss Medical Inc.</name>
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        <name>Illuminoss Inc.</name>
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        <name>Sanofi</name>
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        <name>Axonics Modulation Technologies Inc</name>
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        <name>AC Immune SA</name>
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        <name>Acceleron Pharma Inc</name>
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        <name>Alexion Pharmaceuticals Inc</name>
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        <name>ACADIA Pharmaceuticals Inc</name>
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        <name>Adynxx Inc</name>
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        <name>Axsome Therapeutics Inc</name>
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        <name>Illuminoss Inc.</name>
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        <name>Novavax Inc</name>
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        <name>Bristol-Myers Squibb Co</name>
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        <name>Alkermes PLC</name>
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        <name>ILLUMINOSS INC CONVERTIBLE PROMISSORY NOTE</name>
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        <name>Gilead Sciences Inc</name>
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        <name>Illuminoss Medical Inc.</name>
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        <identifiers>
          <other otherDesc="Internal Identifier" value="932TYG909"/>
        </identifiers>
        <balance>820.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetConditional assetCat="OTHER" desc="Milestone Interest"/>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR Therapeutics AG</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
        </identifiers>
        <balance>23648.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1002911.68000000</valUSD>
        <pctVal>0.249778977088</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illuminoss Inc.</name>
        <lei>N/A</lei>
        <title>Illuminoss Inc. Warrants Call Exp 11Jan28</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="ACI0ZYHR5"/>
        </identifiers>
        <balance>47541.53000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0.00000000</valUSD>
        <pctVal>0.000000</pctVal>
        <payoffProfile>N/A</payoffProfile>
        <assetCat>DE</assetCat>
        <issuerConditional desc="derivative" issuerCat="OTHER"/>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <derivativeInfo>
          <optionSwaptionWarrantDeriv derivCat="WAR">
            <counterparties>
              <counterpartyName>N/A</counterpartyName>
              <counterpartyLei>N/A</counterpartyLei>
            </counterparties>
            <putOrCall>Call</putOrCall>
            <writtenOrPur>Purchased</writtenOrPur>
            <descRefInstrmnt>
              <otherRefInst>
                <issuerName>ILLUMINOSS INC. SERIES AA</issuerName>
                <issueTitle>ILLUMINOSS INC. SERIES AA</issueTitle>
                <identifiers>
                  <other otherDesc="Internal Identifier - Private Company" value="976MND900"/>
                </identifiers>
              </otherRefInst>
            </descRefInstrmnt>
            <shareNo>1.00000000</shareNo>
            <exercisePrice>1.00000000</exercisePrice>
            <exercisePriceCurCd>USD</exercisePriceCurCd>
            <expDt>2028-01-11</expDt>
            <delta>XXXX</delta>
            <unrealizedAppr>-28.60000000</unrealizedAppr>
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        </derivativeInfo>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>Apellis Pharmaceuticals Inc</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
        </identifiers>
        <balance>59588.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1596362.52000000</valUSD>
        <pctVal>0.397580171075</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Curasen Therapeutics, Inc.</name>
        <lei>N/A</lei>
        <title>CURASEN THERAPEUTICS, INC. SERIES A PREFERRED STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="934MMA908"/>
        </identifiers>
        <balance>2719854.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2999998.96000000</valUSD>
        <pctVal>0.747161177239</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Inc</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>Vertex Pharmaceuticals Inc</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
        </identifiers>
        <balance>139382.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33165946.90000000</valUSD>
        <pctVal>8.260105506855</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mylan NV</name>
        <lei>549300A0CD4KNFGIIS89</lei>
        <title>Mylan NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0011031208"/>
        </identifiers>
        <balance>294349.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4388743.59000000</valUSD>
        <pctVal>1.093033321353</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aerpio Pharmaceuticals Inc</name>
        <lei>549300G3U7TKW1M58L09</lei>
        <title>Aerpio Pharmaceuticals Inc</title>
        <cusip>00810B105</cusip>
        <identifiers>
          <isin value="US00810B1052"/>
        </identifiers>
        <balance>79542.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43732.19000000</valUSD>
        <pctVal>0.010891668630</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arrowhead Pharmaceuticals Inc</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>Arrowhead Pharmaceuticals Inc</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
        </identifiers>
        <balance>33666.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>968570.82000000</valUSD>
        <pctVal>0.241226254995</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fate Therapeutics Inc</name>
        <lei>549300L14Q4UHOODLA90</lei>
        <title>Fate Therapeutics Inc</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
        </identifiers>
        <balance>59161.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1313965.81000000</valUSD>
        <pctVal>0.327248193929</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AQUAMED TECHNOLOGIES INC COMMON STOCK</name>
        <lei>N/A</lei>
        <title>AQUAMED TECHNOLOGIES INC COMMON STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="935LTY900"/>
        </identifiers>
        <balance>44550.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2383.43000000</valUSD>
        <pctVal>0.000593602327</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Conversion of Illuminoss Medical, Inc. notes are dependent upon unknown future events therefore underlying reference instrument cannot be determined at this time.                                                                    Conversion of Rainier Therapeutics, Inc. notes are dependent upon unknown future events therefore underlying reference instrument cannot be determined at this time." noteItem="C.9.f.iii"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-04-29</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA LIFE SCIENCES INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
