<SEC-DOCUMENT>0001752724-20-234877.txt : 20201118
<SEC-HEADER>0001752724-20-234877.hdr.sgml : 20201118
<ACCEPTANCE-DATETIME>20201118141442
ACCESSION NUMBER:		0001752724-20-234877
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20200930
FILED AS OF DATE:		20201118
PERIOD START:           	20200930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA LIFE SCIENCES INVESTORS
		CENTRAL INDEX KEY:			0000884121
		IRS NUMBER:				043147016
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-06565
		FILM NUMBER:		201324225

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q LIFE SCIENCES INVESTORS
		DATE OF NAME CHANGE:	19920929
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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      <repPdDate>2020-09-30</repPdDate>
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      <totLiabs>595168.50</totLiabs>
      <netAssets>483570375.90</netAssets>
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        <name>TETRAPHASE PHARMACEUTICALS INC</name>
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              <counterpartyName>N/A</counterpartyName>
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                <issuerName>Tetraphase Pharmaceuticals Inc</issuerName>
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        <name>Kadmon Holdings Inc</name>
        <lei>549300BBVICD23L50606</lei>
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        <name>Bristol-Myers Squibb Co</name>
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        <name>Allakos Inc</name>
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        <name>Alkermes PLC</name>
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        <name>Arrowhead Pharmaceuticals Inc</name>
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        <name>Deciphera Pharmaceuticals Inc</name>
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        <name>Mylan NV</name>
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        <name>Verona Pharma PLC</name>
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        <name>Avadel Pharmaceuticals PLC</name>
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      <invstOrSec>
        <name>Bellicum Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RAINIER THERAPEUTICS, INC CONVERTIBLE PROMISSORY NOTE</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>PRA Health Sciences Inc</name>
        <lei>549300R1HR1VWWHIAK47</lei>
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          <isin value="US69354M1080"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Turning Point Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Axsome Therapeutics Inc</name>
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      <invstOrSec>
        <name>Horizon Therapeutics Plc</name>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Jazz Pharmaceuticals PLC</name>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Inogen Inc</name>
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        <title>Inogen Inc</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
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          <isin value="US64125C1099"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Amarin Corp PLC</name>
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        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Agios Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
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        <fairValLevel>1</fairValLevel>
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        <name>Aerie Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Zogenix Inc</name>
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        <name>NuCana PLC</name>
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        <name>ZYMEWORKS INC</name>
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        <name>RAINIER THERAPEUTICS, INC. CONVERTIBLE PROMISSORY NOTE</name>
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        <name>AMPHIVENA THERAPEUTICS, INC. SERIES C PREFERRED STOCK</name>
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        <name>Bluebird Bio Inc</name>
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        <name>Rainier Therapeutics Series A PREFERRED STOCK</name>
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        <name>Illumina Inc</name>
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        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
        </identifiers>
        <balance>11056.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>992165.44000000</valUSD>
        <pctVal>0.205174983714</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACADIA Pharmaceuticals Inc</name>
        <lei>529900O3044NO0PEA039</lei>
        <title>ACADIA Pharmaceuticals Inc</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
        </identifiers>
        <balance>86352.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3562020.00000000</valUSD>
        <pctVal>0.736608398182</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
        <lei>5299007STZTNN32O9920</lei>
        <title>Biohaven Pharmaceutical Holding Co Ltd</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="VGG111961055"/>
        </identifiers>
        <balance>10482.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>681434.82000000</valUSD>
        <pctVal>0.140917403952</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>VG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
        </identifiers>
        <balance>46595.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1807420.05000000</valUSD>
        <pctVal>0.373765668882</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Conversion of Rainier Therapeutics, Inc. notes are dependent upon unknown future events therefore underlying reference instrument cannot be determined at this time." noteItem="C.9.f.iii"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-10-27</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA LIFE SCIENCES INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
