<SEC-DOCUMENT>0001752724-21-112399.txt : 20210526
<SEC-HEADER>0001752724-21-112399.hdr.sgml : 20210526
<ACCEPTANCE-DATETIME>20210526132418
ACCESSION NUMBER:		0001752724-21-112399
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210331
FILED AS OF DATE:		20210526
PERIOD START:           	20210930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA LIFE SCIENCES INVESTORS
		CENTRAL INDEX KEY:			0000884121
		IRS NUMBER:				043147016
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-06565
		FILM NUMBER:		21964473

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q LIFE SCIENCES INVESTORS
		DATE OF NAME CHANGE:	19920929
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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        <name>Nektar Therapeutics</name>
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        <name>Theravance Biopharma Inc</name>
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      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc</name>
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        <name>Pieris Pharmaceuticals Warrant Series B</name>
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        <name>IO LIGHT HOLDINIGS, INC. SERIES A2 PREFERRED STOCK</name>
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        <name>Spectrum Pharmaceuticals Inc</name>
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        <name>Sage Therapeutics Inc</name>
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        <name>Curasen Therapeutics, Inc.</name>
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        <fairValLevel>3</fairValLevel>
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        <name>ARCA Biopharma, Inc.</name>
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        <name>Adaptive Biotechnologies Corp</name>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Intellia Therapeutics Inc</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>Intellia Therapeutics Inc</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Turning Point Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Turning Point Therapeutics Inc</title>
        <cusip>90041T108</cusip>
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          <isin value="US90041T1088"/>
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        <balance>41021.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc</name>
        <lei>254900HS0ZFRXXSB9D42</lei>
        <title>Apellis Pharmaceuticals Inc</title>
        <cusip>03753U106</cusip>
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          <isin value="US03753U1060"/>
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        <balance>82121.00000000</balance>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Biogen Inc</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>Biogen Inc</title>
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          <isin value="US09062X1037"/>
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        <balance>67462.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Trillium Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Trillium Therapeutics Inc</title>
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          <isin value="CA89620X5064"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc</name>
        <lei>549300CHIMT2EUSNJB60</lei>
        <title>Madrigal Pharmaceuticals Inc</title>
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          <isin value="US5588681057"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>United Therapeutics Corp</name>
        <lei>5299005C4HZL4UWROC14</lei>
        <title>United Therapeutics Corp</title>
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          <isin value="US91307C1027"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ACADIA Pharmaceuticals Inc</name>
        <lei>529900O3044NO0PEA039</lei>
        <title>ACADIA Pharmaceuticals Inc</title>
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          <isin value="US0042251084"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Syneos Health Inc</name>
        <lei>549300F1ZGKDS8P6GU13</lei>
        <title>Syneos Health Inc</title>
        <cusip>87166B102</cusip>
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          <isin value="US87166B1026"/>
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        <balance>91070.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Endo International PLC</name>
        <lei>5493007TBMWZWGZIB256</lei>
        <title>Endo International PLC</title>
        <cusip>000000000</cusip>
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          <isin value="IE00BJ3V9050"/>
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        <balance>29100.00000000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>OCULIS SA</name>
        <lei>N/A</lei>
        <title>OCULIS SA SERIES B2 PREFERRED PREFERRED STOCK</title>
        <cusip>000000000</cusip>
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        <assetCat>EP</assetCat>
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        <invCountry>CH</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Moderna Inc</name>
        <lei>549300EI6OKH5K5Q2G38</lei>
        <title>Moderna Inc</title>
        <cusip>60770K107</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Iovance Biotherapeutics Inc</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>Iovance Biotherapeutics Inc</title>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Verona Pharma PLC</name>
        <lei>213800EVI6O6J3TIAL06</lei>
        <title>Verona Pharma PLC</title>
        <cusip>925050106</cusip>
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          <isin value="US9250501064"/>
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        <balance>315800.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Atreca Inc</name>
        <lei>549300B5CQV1OOXFLU71</lei>
        <title>Atreca Inc</title>
        <cusip>04965G109</cusip>
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        <balance>48919.00000000</balance>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>506700O6IRRIQLT3W370</lei>
        <title>CRISPR Therapeutics AG</title>
        <cusip>000000000</cusip>
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          <isin value="CH0334081137"/>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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        <name>Denali Therapeutics Inc</name>
        <lei>549300ZTQ2HO18L3Q830</lei>
        <title>Denali Therapeutics Inc</title>
        <cusip>24823R105</cusip>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Illumina Inc</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina Inc</title>
        <cusip>452327109</cusip>
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        <name>Sutro Biopharma Inc</name>
        <lei>5493005U6P15VD25P851</lei>
        <title>Sutro Biopharma Inc</title>
        <cusip>869367102</cusip>
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        <fairValLevel>1</fairValLevel>
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        <name>INVETX, INC.</name>
        <lei>N/A</lei>
        <title>INVETX, INC. SERIES A PREFERRED STOCK</title>
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        <name>Mirati Therapeutics Inc</name>
        <lei>529900GYRW59IDQV6N54</lei>
        <title>Mirati Therapeutics Inc</title>
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        <name>Jounce Therapeutics Inc</name>
        <lei>5493004MZJQIV2K8ZT61</lei>
        <title>Jounce Therapeutics Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Nkarta Inc</name>
        <lei>N/A</lei>
        <title>Nkarta Inc</title>
        <cusip>65487U108</cusip>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Rainier Therapeutics Series A PREFERRED STOCK</name>
        <lei>N/A</lei>
        <title>Rainier Therapeutics Series A PREFERRED STOCK</title>
        <cusip>000000000</cusip>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>ARCA biopharma Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Molecular Templates Inc</name>
        <lei>529900VZKP6N0B8U5F61</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Guardant Health Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Zogenix Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Precision BioSciences Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Intra-Cellular Therapies Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Incyte Corp</name>
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        <fairValLevel>1</fairValLevel>
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        <name>THEROX MILESTONE INTEREST</name>
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        <fairValLevel>3</fairValLevel>
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        <name>Reata Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>HOTSPOT THERAPEUTICS, INC. SERIES B PREFERRED STOCK</name>
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        <name>Fate Therapeutics Inc</name>
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        <name>TCR2 Therapeutics Inc</name>
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        <name>Amgen Inc</name>
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        <title>Amgen Inc</title>
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        <name>Karuna Therapeutics Inc</name>
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        <name>PRA Health Sciences Inc</name>
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        <name>Allakos Inc</name>
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        <name>Ovid therapeutics Inc</name>
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        <name>Replimune Group Inc</name>
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        <name>Medpace Holdings Inc</name>
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        <name>Fixed Income Clearing Corp</name>
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        <name>Corbus Pharmaceuticals Holdings Inc</name>
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        <name>AMPHIVENA THERAPEUTICS, INC. SERIES C PREFERRED STOCK</name>
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        <name>Pieris Pharmaceuticals Inc</name>
        <lei>254900AJDH8PAOOI5T33</lei>
        <title>Pieris Pharmaceuticals Inc</title>
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        <name>Blueprint Medicines Corp</name>
        <lei>5299004CC60O9T5HVM83</lei>
        <title>Blueprint Medicines Corp</title>
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        <name>Ardelyx Inc</name>
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        <name>Jazz Pharmaceuticals PLC</name>
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        <name>Sarepta Therapeutics Inc</name>
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        <name>Argenx SE</name>
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        <name>Zai Lab Ltd</name>
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        <name>I-Mab</name>
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        <name>Vir Biotechnology Inc</name>
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      <invstOrSec>
        <name>CARIBOU BIOSCIENCES</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Arvinas Inc</name>
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        <name>BeiGene Ltd</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Cogent Biosciences Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Neurocrine Biosciences Inc</name>
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        <name>Affimed NV</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Editas Medicine Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>AMPHIVENA THERAPEUTICS, INC. SERIES B PREFERRED STOCK</name>
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        <fairValLevel>3</fairValLevel>
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        <name>Forma Therapeutics Holdings Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>PRIOTHERA LIMITED</name>
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        <fairValLevel>3</fairValLevel>
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        <name>Regeneron Pharmaceuticals Inc</name>
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        <name>Pieris Pharmaceuticals Warrant Series A</name>
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        <name>VECTIVBIO HOLDING AG</name>
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        <name>Arena Pharmaceuticals Inc</name>
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        <name>Aurinia Pharmaceuticals Inc</name>
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        <name>Personalis Inc</name>
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        <name>Alkermes PLC</name>
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        <name>Alexion Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>Rainier Therapeutics Series B PREFERRED STOCK</name>
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        <name>Amicus Therapeutics Inc</name>
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        <title>Amicus Therapeutics Inc</title>
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        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corp</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>Scholar Rock Holding Corp</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
        </identifiers>
        <balance>17193.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>870997.38000000</valUSD>
        <pctVal>0.173270321759</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Galera Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Galera Therapeutics Inc</title>
        <cusip>36338D108</cusip>
        <identifiers>
          <isin value="US36338D1081"/>
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        <balance>145858.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1286467.56000000</valUSD>
        <pctVal>0.255921146460</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
        </identifiers>
        <balance>36998.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6708107.38000000</valUSD>
        <pctVal>1.334465465472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bellicum Pharmaceuticals Inc</name>
        <lei>529900HBXNLX2TBQZQ65</lei>
        <title>Bellicum Pharmaceuticals Inc</title>
        <cusip>079481404</cusip>
        <identifiers>
          <isin value="US0794814048"/>
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        <balance>6000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22560.00000000</valUSD>
        <pctVal>0.004487933659</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>N/A</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>42765.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1440752.85000000</valUSD>
        <pctVal>0.286613617477</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cymabay Therapeutics Inc</name>
        <lei>549300YT9GNL852E7F84</lei>
        <title>Cymabay Therapeutics Inc</title>
        <cusip>23257D103</cusip>
        <identifiers>
          <isin value="US23257D1037"/>
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        <balance>32636.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>148167.44000000</valUSD>
        <pctVal>0.029475427357</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cercacor Laboratories Inc</name>
        <lei>N/A</lei>
        <title>CERCACOR LABORATORIES INC COMMON STOCK</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="574992913"/>
        </identifiers>
        <balance>130000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1429689.82000000</valUSD>
        <pctVal>0.284412813190</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
        </identifiers>
        <balance>8329.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4075462.99000000</valUSD>
        <pctVal>0.810745014634</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Black Diamond Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Black Diamond Therapeutics Inc</title>
        <cusip>09203E105</cusip>
        <identifiers>
          <isin value="US09203E1055"/>
        </identifiers>
        <balance>41586.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1008876.36000000</valUSD>
        <pctVal>0.200699032541</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>551520.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35644737.60000000</valUSD>
        <pctVal>7.090922768299</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2021-04-28</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA LIFE SCIENCES INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
