<SEC-DOCUMENT>0001752724-22-119814.txt : 20220525
<SEC-HEADER>0001752724-22-119814.hdr.sgml : 20220525
<ACCEPTANCE-DATETIME>20220525112137
ACCESSION NUMBER:		0001752724-22-119814
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20220331
FILED AS OF DATE:		20220525
PERIOD START:           	20220930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA LIFE SCIENCES INVESTORS
		CENTRAL INDEX KEY:			0000884121
		IRS NUMBER:				043147016
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-06565
		FILM NUMBER:		22960424

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q LIFE SCIENCES INVESTORS
		DATE OF NAME CHANGE:	19920929
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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        <name>Impact Biomedicines Milestone</name>
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        <name>VectivBio Holding AG</name>
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        <name>ARKUDA THERAPEUTICS,INC SER A.</name>
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        <name>ChemoCentryx Inc</name>
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        <name>Repare Therapeutics Inc</name>
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        <name>BioMarin Pharmaceutical Inc</name>
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        <name>IO LIGHT HOLDINIGS, INC.</name>
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        <name>Verona Pharma PLC</name>
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        <name>Ascendis Pharma A/S</name>
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        <name>Fixed Income Clearing Corp</name>
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        <name>Endo International PLC</name>
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        <name>Verona Pharma PLC</name>
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        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
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        <name>Options Clearing Corp.</name>
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        <name>Avidity Biosciences Inc</name>
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        <name>Jazz Pharmaceuticals PLC</name>
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        <name>I-Mab</name>
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      <invstOrSec>
        <name>THERACHON MILESTONE INTEREST</name>
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      <invstOrSec>
        <name>Arcutis Biotherapeutics Inc</name>
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      <invstOrSec>
        <name>Design Therapeutics Inc</name>
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      <invstOrSec>
        <name>Arvinas Inc</name>
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      <invstOrSec>
        <name>BeiGene Ltd</name>
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          <isin value="US07725L1026"/>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ALX Oncology Holdings Inc</name>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Neurocrine Biosciences Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Affimed NV</name>
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        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SPDR S&amp;P Biotech ETF</name>
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        <title>SPDR S&amp;P Biotech ETF</title>
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        <fairValLevel>1</fairValLevel>
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        <name>AMPHIVENA THERAPEUTICS, INC.</name>
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        <fairValLevel>3</fairValLevel>
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        <name>Nexgel Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>PRIOTHERA LIMITED</name>
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        <name>Cytokinetics Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Regeneron Pharmaceuticals Inc</name>
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        <name>VYNE Therapeutics Inc</name>
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      <invstOrSec>
        <name>State Street Institutional US Government Money Market Fund</name>
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        <name>Syndax Pharmaceuticals Inc</name>
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        <name>Biohaven Pharmaceutical Holding Co Ltd</name>
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        <name>Aurinia Pharmaceuticals Inc</name>
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        <name>Options Clearing Corp.</name>
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        <name>Alkermes PLC</name>
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        <isRestrictedSec>N</isRestrictedSec>

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        <name>Scholar Rock Holding Corp</name>
        <lei>549300Z1FLPGL4OWJ459</lei>
        <title>Scholar Rock Holding Corp</title>
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        <curCd>USD</curCd>
        <valUSD>524829.24000000</valUSD>
        <pctVal>0.120518882290</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Galera Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Galera Therapeutics Inc</title>
        <cusip>36338D108</cusip>
        <identifiers>
          <isin value="US36338D1081"/>
        </identifiers>
        <balance>125773.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>299339.74000000</valUSD>
        <pctVal>0.068738721359</pctVal>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="80444.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc</name>
        <lei>529900J4GJHPEPQ23205</lei>
        <title>Novavax Inc</title>
        <cusip>670002401</cusip>
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          <isin value="US6700024010"/>
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        <curCd>USD</curCd>
        <valUSD>1959973.80000000</valUSD>
        <pctVal>0.450077537017</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="1855980.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bellicum Pharmaceuticals Inc</name>
        <lei>529900HBXNLX2TBQZQ65</lei>
        <title>Bellicum Pharmaceuticals Inc</title>
        <cusip>079481404</cusip>
        <identifiers>
          <isin value="US0794814048"/>
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        <balance>6000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>12960.00000000</valUSD>
        <pctVal>0.002976062679</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure NV</name>
        <lei>N/A</lei>
        <title>uniQure NV</title>
        <cusip>000000000</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
        </identifiers>
        <balance>164613.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2974556.91000000</valUSD>
        <pctVal>0.683060787737</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cercacor Laboratories Inc</name>
        <lei>N/A</lei>
        <title>CERCACOR LABORATORIES INC</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="574992913"/>
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        <balance>130000.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>632299.85000000</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
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        <balance>5826.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3187171.56000000</valUSD>
        <pctVal>0.731884439362</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fulcrum Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Fulcrum Therapeutics Inc</title>
        <cusip>359616109</cusip>
        <identifiers>
          <isin value="US3596161097"/>
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        <balance>77293.00000000</balance>
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        <curCd>USD</curCd>
        <valUSD>1827979.45000000</valUSD>
        <pctVal>0.419767084935</pctVal>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>Xencor Inc</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
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        <balance>33162.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>884762.16000000</valUSD>
        <pctVal>0.203171886185</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNEID, INC. SERIES A</name>
        <lei>N/A</lei>
        <title>IMMUNEID, INC. SERIES A</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="942RVA907"/>
        </identifiers>
        <balance>480000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>960000.00000000</valUSD>
        <pctVal>0.220449087399</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Black Diamond Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Black Diamond Therapeutics Inc</title>
        <cusip>09203E105</cusip>
        <identifiers>
          <isin value="US09203E1055"/>
        </identifiers>
        <balance>41586.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>115193.22000000</valUSD>
        <pctVal>0.026452333566</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="109415.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>513799.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>30545350.55000000</valUSD>
        <pctVal>7.014265263591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>

    </explntrNotes>
    <signature>
      <ncom:dateSigned>2022-04-21</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA LIFE SCIENCES INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
