<SEC-DOCUMENT>0001752724-23-100530.txt : 20230515
<SEC-HEADER>0001752724-23-100530.hdr.sgml : 20230515
<ACCEPTANCE-DATETIME>20230515144144
ACCESSION NUMBER:		0001752724-23-100530
CONFORMED SUBMISSION TYPE:	NPORT-P
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20230331
FILED AS OF DATE:		20230515
DATE AS OF CHANGE:		20230515
PERIOD START:           	20230930

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TEKLA LIFE SCIENCES INVESTORS
		CENTRAL INDEX KEY:			0000884121
		IRS NUMBER:				043147016
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			0930

	FILING VALUES:
		FORM TYPE:		NPORT-P
		SEC ACT:		1940 Act
		SEC FILE NUMBER:	811-06565
		FILM NUMBER:		23921078

	BUSINESS ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		6177728515

	MAIL ADDRESS:	
		STREET 1:		100 FEDERAL STREET
		STREET 2:		19TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	H&Q LIFE SCIENCES INVESTORS
		DATE OF NAME CHANGE:	19920929
</SEC-HEADER>
<DOCUMENT>
<TYPE>NPORT-P
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>Caribou Biosciences Inc</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Impact Biomedicines Milestone</name>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Harpoon Therapeutics Inc</name>
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          <isin value="US41358P1066"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>HOTSPOT THERAPEUTICS, INC.</name>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>G1 Therapeutics Inc</name>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Adicet Bio Inc</name>
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          <isin value="US0070021086"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Merus NV</name>
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        <assetCat>EC</assetCat>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARKUDA THERAPEUTICS, INC.</name>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Prometheus Biosciences Inc</name>
        <lei>N/A</lei>
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          <isin value="US74349U1088"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>VectivBio Holding AG</name>
        <lei>N/A</lei>
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          <isin value="CH1109007893"/>
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        <assetCat>EC</assetCat>
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        <invCountry>CH</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ARKUDA THERAPEUTICS,INC SER A.</name>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Repare Therapeutics Inc</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Chinook Therapeutics Inc</name>
        <lei>549300X0O3003W5QYQ48</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>IO LIGHT HOLDINIGS, INC.</name>
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        <name>Spectrum Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Curasen Therapeutics, Inc.</name>
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        <name>Beam Therapeutics Inc</name>
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        <name>Adaptive Biotechnologies Corp</name>
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        <name>Travere Therapeutics Inc</name>
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        <name>ARISTEA THERAPEUTICS, INC.</name>
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        <name>QUELL THERAPEUTICS</name>
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        <name>Afferent Milestone Interest</name>
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      <invstOrSec>
        <name>Praxis Precision Medicines Inc</name>
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      <invstOrSec>
        <name>Seagen Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>RECODE THERAPEUTICS</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>ETHISMOS RESEARCH, INC. MILEST</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Intellia Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Marinus Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Apellis Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Biogen Inc</name>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>FUSION PHARMACEUTICALS, INC.</name>
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        <fairValLevel>2</fairValLevel>
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        <name>United Therapeutics Corp</name>
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        <fairValLevel>1</fairValLevel>
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        <name>IQVIA Holdings Inc</name>
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        <name>Endo International PLC</name>
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        <invCountry>IE</invCountry>

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        <fairValLevel>1</fairValLevel>
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        <name>Moderna Inc</name>
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        <name>Biohaven Ltd</name>
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        <name>Mersana Therapeutics Inc</name>
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        <name>HIBERCELL, INC. SERIES B</name>
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        <name>AstraZeneca PLC</name>
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        <name>AMOLYT PHARMA SAS</name>
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        <name>PARTHENON THERAPEUTICS, INC.</name>
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        <name>CRISPR Therapeutics AG</name>
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        <name>Denali Therapeutics Inc</name>
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        <name>Illumina Inc</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina Inc</title>
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        <name>Mirati Therapeutics Inc</name>
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        <name>Nkarta Inc</name>
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        <name>Cerevel Therapeutics Holdings Inc</name>
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        <name>ARCA biopharma Inc</name>
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        <name>Guardant Health Inc</name>
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        <name>Precision BioSciences Inc</name>
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        <name>Intra-Cellular Therapies Inc</name>
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        <name>THEROX MILESTONE INTEREST</name>
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        <name>Reata Pharmaceuticals Inc</name>
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        <name>HOTSPOT THERAPEUTICS, INC.</name>
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        <name>Theseus Pharmaceuticals Inc</name>
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        <name>Amgen Inc</name>
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        <name>ENDEAVOR BIOMEDICINES, INC.</name>
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        <name>Karuna Therapeutics Inc</name>
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        <name>Medpace Holdings Inc</name>
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        <name>Pyxis Oncology Inc</name>
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        <name>Vaxcyte Inc</name>
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        <name>Blueprint Medicines Corp</name>
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        <name>Bridgebio Pharma Inc</name>
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        <name>Bicycle Therapeutics PLC</name>
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        <name>BIOTHERYX, INC. SERIES E</name>
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          <other otherDesc="Internal Identifier" value="931UVM907"/>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>iTeos Therapeutics Inc</name>
        <lei>N/A</lei>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Ardelyx Inc</name>
        <lei>549300F542QR4SXHCY32</lei>
        <title>Ardelyx Inc</title>
        <cusip>039697107</cusip>
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          <isin value="US0396971071"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Jazz Pharmaceuticals PLC</name>
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          <isin value="IE00B4Q5ZN47"/>
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        <assetCat>EC</assetCat>
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        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Edgewise Therapeutics Inc</name>
        <lei>N/A</lei>
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          <isin value="US28036F1057"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Sarepta Therapeutics Inc</name>
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          <isin value="US8036071004"/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Argenx SE</name>
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        <title>Argenx SE</title>
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          <isin value="US04016X1019"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>INNOVACARE INC</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>TETRAPHASE PHARMACEUTICALS INC</name>
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        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
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              <counterpartyName>N/A</counterpartyName>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>DYNACURE</name>
        <lei>N/A</lei>
        <title>DYNACURE</title>
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        <assetCat>EP</assetCat>
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        <invCountry>FR</invCountry>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Zai Lab Ltd</name>
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        <title>Zai Lab Ltd</title>
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        <assetCat>EC</assetCat>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Fusion Pharmaceuticals Inc</name>
        <lei>N/A</lei>
        <title>Fusion Pharmaceuticals Inc</title>
        <cusip>36118A100</cusip>
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        <assetCat>EC</assetCat>
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        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>I-Mab</name>
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        <title>I-Mab</title>
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        <assetCat>EC</assetCat>
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        <invCountry>KY</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Ultragenyx Pharmaceutical Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Arcus Biosciences Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>Corbus Pharmaceuticals Holdings Inc</name>
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        <fairValLevel>1</fairValLevel>
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        <name>INVETX, INC.</name>
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        <name>THERACHON MILESTONE INTEREST</name>
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        <name>Arcutis Biotherapeutics Inc</name>
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        <name>BeiGene Ltd</name>
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        <name>Altimmune Inc</name>
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        <name>ALX Oncology Holdings Inc</name>
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        <name>Natera Inc</name>
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        <title>Natera Inc</title>
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        <fairValLevel>1</fairValLevel>
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        <name>Neurocrine Biosciences Inc</name>
        <lei>549300FECER0XBN49756</lei>
        <title>Neurocrine Biosciences Inc</title>
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      <invstOrSec>
        <name>Exelixis Inc</name>
        <lei>254900PJQB59O2O95R37</lei>
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      <invstOrSec>
        <name>Affimed NV</name>
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        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>SPDR S&amp;P Biotech ETF</name>
        <lei>549300Y3ODFMPD5XXL58</lei>
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          <isin value="US78464A8707"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Crinetics Pharmaceuticals Inc</name>
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      <invstOrSec>
        <name>Nexgel Inc</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>PRIOTHERA LIMITED</name>
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        <invCountry>IE</invCountry>
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        <fairValLevel>3</fairValLevel>
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        <name>Lantheus Holdings Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cytokinetics Inc</name>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Regeneron Pharmaceuticals Inc</name>
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        <name>VYNE Therapeutics Inc</name>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>State Street Institutional US Government Money Market Fund</name>
        <lei>N/A</lei>
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          <ticker value="SAHXX"/>
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        <assetCat>STIV</assetCat>
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        <name>AMPHIVENA MILESTONE INTEREST</name>
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        <fairValLevel>3</fairValLevel>
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      <invstOrSec>
        <name>Syndax Pharmaceuticals Inc</name>
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        <name>Immunovant Inc</name>
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        <name>Alkermes PLC</name>
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          <isCashCollateral>N</isCashCollateral>
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        <name>Codexis Inc</name>
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        <name>89bio Inc</name>
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        <name>Scholar Rock Holding Corp</name>
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        <name>Eli Lilly &amp; Co</name>
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        <name>Galera Therapeutics Inc</name>
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        <name>Novavax Inc</name>
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        <name>Bellicum Pharmaceuticals Inc</name>
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        <name>uniQure NV</name>
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        <name>Cercacor Laboratories Inc</name>
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        <fairValLevel>3</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEXX Laboratories Inc</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX Laboratories Inc</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
        </identifiers>
        <balance>2989.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1494739.12000000</valUSD>
        <pctVal>0.353662940521</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fulcrum Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Fulcrum Therapeutics Inc</title>
        <cusip>359616109</cusip>
        <identifiers>
          <isin value="US3596161097"/>
        </identifiers>
        <balance>58537.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>166830.45000000</valUSD>
        <pctVal>0.039472939943</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IMMUNEID, INC. SERIES A</name>
        <lei>N/A</lei>
        <title>IMMUNEID, INC. SERIES A</title>
        <cusip>000000000</cusip>
        <identifiers>
          <other otherDesc="Internal Identifier" value="942RVA907"/>
        </identifiers>
        <balance>480000.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>960000.00000000</valUSD>
        <pctVal>0.227140922692</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Black Diamond Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>Black Diamond Therapeutics Inc</title>
        <cusip>09203E105</cusip>
        <identifiers>
          <isin value="US09203E1055"/>
        </identifiers>
        <balance>41586.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>78597.54000000</valUSD>
        <pctVal>0.018596580996</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <loanByFundCondition isLoanByFund="Y" loanVal="73143.00000000"/>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>Gilead Sciences Inc</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
        </identifiers>
        <balance>441671.00000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36645442.87000000</valUSD>
        <pctVal>8.670499693697</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2023-04-24</ncom:dateSigned>
      <ncom:nameOfApplicant>TEKLA LIFE SCIENCES INVESTORS</ncom:nameOfApplicant>
      <ncom:signature>Laura Woodward</ncom:signature>
      <ncom:signerName>Laura Woodward</ncom:signerName>
      <ncom:title>CCO</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
