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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Operating activities    
Net loss $ (51,275) $ (40,157)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization of premium on marketable securities 840 268
Depreciation and amortization 765 858
Stock-based compensation expense 7,866 6,128
Gain (loss) on foreign currency translation 281 (65)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 379 401
Accounts payable, accrued expenses and other current liabilities 3,551 5,207
Deferred revenue (2,676) 2,260
Deferred rent (76) (25)
Net cash used in operating activities (40,345) (25,125)
Investing activities    
Purchase of marketable securities (148,050) (122,706)
Proceeds from maturities of marketable securities 82,956 20,000
Purchase of property and equipment (361) (224)
Net cash used in investing activities (65,455) (102,930)
Financing activities    
Proceeds from issuance of common stock under employee stock plans 1,609 648
Net cash provided by financing activities 140,881 70,901
Net increase (decrease) in cash and cash equivalents 35,081 (57,154)
Cash and cash equivalents at beginning of period 24,918 77,383
Cash and cash equivalents at end of period 59,999 20,229
Supplemental disclosures of non-cash investing and financing information    
Issuance costs related to public offering included in accrued expenses 370 0
Public Offering    
Financing activities    
Proceeds from issuance of common stock, net of issuance costs 134,582 69,842
At The Market    
Financing activities    
Proceeds from issuance of common stock, net of issuance costs $ 4,690 $ 411