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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Income Statement [Abstract] |  |
Revenue | $ 3,813 | $ 5,042
Operating expenses: |  |
Research and development | 56,985 | 45,485
General and administrative | 16,037 | 12,771
Total operating expenses | 73,022 | 58,256
Loss from operations | (69,209) | (53,214)
Other income, net | 5 | 1,312
Net loss before taxes | (69,204) | (51,902)
Provision for income taxes |  | 990
Net loss | (69,204) | (52,892)
Other comprehensive income (loss): |  |
Foreign currency translation gain (loss) | 258 | (249)
Unrealized gain (loss) on marketable securities | (287) | 52
Total comprehensive loss | $ (69,233) | $ (53,089)
Net loss per share, basic and diluted | $ (2.53) | $ (2.19)
Weighted average number of shares used in computing net loss per share, basic and diluted | 27,390,326 | 24,134,305

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