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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2021
Income Tax Disclosure [Abstract] |
Schedule of Domestic and Foreign Components of Income (Loss) before Income Taxes | The following table presents domestic and foreign components of income (loss) before income taxes for the periods presented (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
United States |  | $ | (66,464 | ) |  | $ | (49,961 | )
Foreign |  |  | (2,740 | ) |  |  | (1,941 | )
|  | $ | (69,204 | ) |  | $ | (51,902 | )
Schedule of Components of Provision for Income Taxes | The components of the provision for income taxes related to Korean withholding taxes on the near-term milestone payment the Company received pursuant to the Hanmi Agreement are as follows (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Current |  |  |  |  |  |  |  |
Foreign |  |  | — |  |  | $ | 990 |
Total provision for income taxes |  | $ | — |  |  | $ | 990 |
Schedule of Effective Income Tax Rate Reconciliation | A reconciliation of the statutory U.S. federal rate and effective rate is as follows:
|  | December 31, |
|  | 2021 |  |  | 2020 |
Federal tax |  |  | 21.00 | % |  |  | 21.00 | %
Stock-based compensation |  |  | (0.76 | ) |  |  | (0.55 | )
Research and development tax credit |  |  | 2.39 |  |  |  | 2.83 |
Foreign losses not benefited |  |  | (2.14 | ) |  |  | — |
Withholding taxes, net of federal benefit |  |  | — |  |  |  | (1.51 | )
Change in valuation allowance |  |  | (20.86 | ) |  |  | (23.99 | )
Other |  |  | 0.37 |  |  |  | 0.31 |
Income tax expense |  |  | — | % |  |  | (1.91 | %)
Schedule of Components of Deferred Tax Assets and Liabilities | The components of the Company’s deferred tax assets and liabilities are as follows (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 49,791 |  |  | $ | 38,665 |
Federal and state research and development tax credits |  |  | 7,756 |  |  |  | 6,103 |
Accrued liabilities and reserves |  |  | 1,644 |  |  |  | 1,089 |
Stock-based compensation |  |  | 2,331 |  |  |  | 1,273 |
Gross deferred tax assets |  |  | 61,522 |  |  |  | 47,130 |
Valuation allowance |  |  | (61,488 | ) |  |  | (47,060 | )
Deferred tax liabilities: |  |  |  |  |  |  |  |
Depreciation and amortization |  |  | (34 | ) |  |  | (70 | )
Gross deferred tax liabilities |  |  | (34 | ) |  |  | (70 | )
Net deferred taxes |  | $ | — |  |  | $ | — |
Schedule of Reconciliation of Unrecognized Tax Benefits | A reconciliation of the beginning and ending amounts of unrecognized tax benefits for the years ended December 31, 2021 and 2020 resulting primarily from research and development tax credits claimed for both US and foreign operations on the Company’s annual tax returns were as follows (in thousands):
|  | December 31, |
|  | 2021 |  |  | 2020 |
Balance at beginning of year |  | $ | 2,291 |  |  | $ | 1,747 |
Additions on tax positions related to prior years |  |  | 807 |  |  |  | — |
Additions on tax positions related to current year |  |  | 1,336 |  |  |  | 544 |
Balance at end of year |  | $ | 4,434 |  |  | $ | 2,291 |

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