<SEC-DOCUMENT>0000899243-22-019470.txt : 20220525
<SEC-HEADER>0000899243-22-019470.hdr.sgml : 20220525
<ACCEPTANCE-DATETIME>20220525161950
ACCESSION NUMBER:		0000899243-22-019470
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20220523
FILED AS OF DATE:		20220525
DATE AS OF CHANGE:		20220525

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GOEDDEL DAVID V
		CENTRAL INDEX KEY:			0001182464

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963155

	MAIL ADDRESS:	
		STREET 1:		C/O COLUMN GROUP LP
		STREET 2:		1700 OWENS STREET, SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			COLUMN GROUP II, LP
		CENTRAL INDEX KEY:			0001600420
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963162

	BUSINESS ADDRESS:	
		STREET 1:		1700 OWENS STREET
		STREET 2:		SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158
		BUSINESS PHONE:		4158652050

	MAIL ADDRESS:	
		STREET 1:		1700 OWENS STREET
		STREET 2:		SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Svennilson Peter
		CENTRAL INDEX KEY:			0001606074

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963154

	MAIL ADDRESS:	
		STREET 1:		1700 OWENS STREET
		STREET 2:		SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Kutzkey Tim
		CENTRAL INDEX KEY:			0001614186

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963156

	MAIL ADDRESS:	
		STREET 1:		1700 OWENS STREET
		STREET 2:		SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ponoi II Management, LLC
		CENTRAL INDEX KEY:			0001746488
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963157

	BUSINESS ADDRESS:	
		STREET 1:		1 LETTERMAN DRIVE
		STREET 2:		BUILDING D, SUITE M-900
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94129
		BUSINESS PHONE:		415-865-2050

	MAIL ADDRESS:	
		STREET 1:		1 LETTERMAN DRIVE
		STREET 2:		BUILDING D, SUITE M-900
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94129

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Column Group LLC
		CENTRAL INDEX KEY:			0001833486
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963153

	BUSINESS ADDRESS:	
		STREET 1:		LETTERMAN DRIVE, BUILDING D, SUITE M-900
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94129
		BUSINESS PHONE:		415-865-2050

	MAIL ADDRESS:	
		STREET 1:		LETTERMAN DRIVE, BUILDING D, SUITE M-900
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94129

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			PONOI CAPITAL, LP
		CENTRAL INDEX KEY:			0001707230
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963160

	BUSINESS ADDRESS:	
		STREET 1:		1700 OWENS STREET
		STREET 2:		SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158
		BUSINESS PHONE:		3123606645

	MAIL ADDRESS:	
		STREET 1:		1700 OWENS STREET
		STREET 2:		SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ponoi Management, LLC
		CENTRAL INDEX KEY:			0001720702
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963159

	BUSINESS ADDRESS:	
		STREET 1:		1 LETTERMAN DRIVE
		STREET 2:		BUILDING D, SUITE M-900
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94129
		BUSINESS PHONE:		4158652050

	MAIL ADDRESS:	
		STREET 1:		1 LETTERMAN DRIVE
		STREET 2:		BUILDING D, SUITE M-900
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94129

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ponoi Capital II, LP
		CENTRAL INDEX KEY:			0001732601
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963158

	BUSINESS ADDRESS:	
		STREET 1:		1700 OWENS STREET
		STREET 2:		STE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158
		BUSINESS PHONE:		4158652050

	MAIL ADDRESS:	
		STREET 1:		1700 OWENS STREET
		STREET 2:		STE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Column Group II GP, LP
		CENTRAL INDEX KEY:			0001645333
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-38997
		FILM NUMBER:		22963161

	BUSINESS ADDRESS:	
		STREET 1:		1700 OWENS STREET, SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158
		BUSINESS PHONE:		415-865-2050

	MAIL ADDRESS:	
		STREET 1:		1700 OWENS STREET, SUITE 500
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94158

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RAPT Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001673772
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				473313701
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		561 ECCLES AVENUE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		(650) 489-9000

	MAIL ADDRESS:	
		STREET 1:		561 ECCLES AVENUE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FLX Bio, Inc.
		DATE OF NAME CHANGE:	20160504
</SEC-HEADER>
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<SEQUENCE>1
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            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
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            <rptOwnerStreet2>BUILDING D, SUITE DM-900</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94129</rptOwnerZipCode>
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            <rptOwnerStreet2>BUILDING D, SUITE DM-900</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94129</rptOwnerZipCode>
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    <reportingOwner>
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            <rptOwnerCik>0001614186</rptOwnerCik>
            <rptOwnerName>Kutzkey Tim</rptOwnerName>
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        <reportingOwnerAddress>
            <rptOwnerStreet1>1 LETTERMAN DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>BUILDING D, SUITE DM-900</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94129</rptOwnerZipCode>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001182464</rptOwnerCik>
            <rptOwnerName>GOEDDEL DAVID V</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1 LETTERMAN DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>BUILDING D, SUITE DM-900</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94129</rptOwnerZipCode>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001606074</rptOwnerCik>
            <rptOwnerName>Svennilson Peter</rptOwnerName>
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        <reportingOwnerAddress>
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            <rptOwnerStreet2>BUILDING D, SUITE DM-900</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94129</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001833486</rptOwnerCik>
            <rptOwnerName>Column Group LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1 LETTERMAN DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>BUILDING D, SUITE DM-900</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94129</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isOther>0</isOther>
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    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-05-23</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>9898</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>12.4993</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1218648</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-05-23</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>338</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>12.4993</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>41588</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-05-24</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
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            <transactionAmounts>
                <transactionShares>
                    <value>15776</value>
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                <transactionPricePerShare>
                    <value>12.0021</value>
                    <footnoteId id="F4"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1234424</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-05-24</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>538</value>
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                <transactionPricePerShare>
                    <value>12.0021</value>
                    <footnoteId id="F4"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>42126</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1402008</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F5"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>163</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1599417</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F7"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>145401</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F8"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $12.44 to $12.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the ranges set forth in this footnote (1) to this Form 4.</footnote>
        <footnote id="F2">The securities are directly held by The Column Group IV, LP (&quot;TCG IV LP&quot;). The Column Group IV GP, LP (&quot;TCG IV GP LP&quot;) is the general partner of TCG IV LP and may be deemed to have voting and investment power with respect to these securities. TCG IV GP LLC (&quot;TCG IV LLC&quot;) is the general partner of TCG IV GP LP and the ultimate general partner of TCG IV LP and may be deemed to have voting and investment power with respect to these securities. The managing members of TCG IV LLC are David Goeddel, a member of the issuer's board of directors, Peter Svennilson and Tim Kutzkey (collectively, the &quot;TCG IV Managing Members&quot;). The TCG IV Managing Members may be deemed to share voting and investment power with respect to such securities. TCG IV GP LP, TCG IV LLC and each of the TCG IV Managing Members disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.</footnote>
        <footnote id="F3">The securities are directly held by The Column Group IV-A, LP (&quot;TCG IV-A LP&quot;). TCG IV GP LP is the general partner of TCG IV-A LP and may be deemed to have voting and investment power with respect to these securities. TCG IV LLC is the general partner of TCG IV GP LP and the ultimate general partner of TCG IV-A LP and may be deemed to have voting and investment power with respect to these securities. The managing members of TCG IV LLC are the TCG IV Managing Members. The TCG IV Managing Members may be deemed to share voting and investment power with respect to such securities. TCG IV GP LP, TCG IV LLC and each of the TCG IV Managing Members disclaim beneficial ownership of these securities, except to the extent of their respective pecuniary interest in such securities.</footnote>
        <footnote id="F4">The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $11.605 to $12.25, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the ranges set forth in this footnote (4) to this Form 4.</footnote>
        <footnote id="F5">The securities are directly held by The Column Group II, LP (&quot;TCG II LP&quot;). The Column Group II GP, LP (&quot;TCG II GP&quot;) is the general partner of TCG II LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of TCG II GP are David Goeddel and Peter Svennilson (collectively, the &quot;TCG II GP Managing Partners&quot;). The TCG II GP Managing Partners may be deemed to share voting and investment power with respect to such shares. TCG II GP and each of the TCG II GP Managing Partners disclaim beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.</footnote>
        <footnote id="F6">The securities are directly held The Column Group LLC (&quot;TCG LLC&quot;). The managing members of TCG LLC are the TCG II GP Managing Partners and Tim Kutzkey (collectively, the &quot;Ponoi Managing Partners&quot;). The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares. Each of the Ponoi Managing Partners disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.</footnote>
        <footnote id="F7">The securities are directly held by Ponoi Capital, LP (&quot;Ponoi LP&quot;). Ponoi Management, LLC (&quot;Ponoi LLC&quot;) is the general partner of Ponoi LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of Ponoi LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares. Ponoi LLC and the each of the Ponoi Managing Partners disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.</footnote>
        <footnote id="F8">The securities are directly held by Ponoi Capital II, LP (&quot;Ponoi II LP&quot;). Ponoi II Management, LLC (&quot;Ponoi II LLC&quot;) is the general partner of Ponoi II LP and may be deemed to have voting, investment and dispositive power with respect to these securities. The managing partners of Ponoi II LLC are the Ponoi Managing Partners. The Ponoi Managing Partners may be deemed to share voting and investment power with respect to such shares. Ponoi II LLC and the each of the Ponoi Managing Partners disclaims beneficial ownership of these shares, except to the extent of their respective pecuniary interest in such shares.</footnote>
    </footnotes>

    <remarks>Due to SEC restrictions on the number of reporting owners, this is Form 1 of 2.</remarks>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for David Goeddel</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for Peter Svennilson</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for Tim Kutzkey</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for Ponoi Capital II LP</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for Ponoi II Management LLC</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for Ponoi Capital LP</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for Ponoi Management LLC</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for The Column Group II LP</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for The Column Group II GP LP</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ James Evangelista, as Attorney-in-fact for The Column Group LLC</signatureName>
        <signatureDate>2022-05-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
