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Income Taxes (Tables)
 3 Months Ended
Mar. 31, 2018
Income Tax Disclosure [Abstract]  
Reconciliation of effective tax rate to the U.S. federal statutory tax rate
A reconciliation of the U.S. federal statutory tax rate to the Company’s effective income tax rate is as follows:
 
Three months ended March 31,
 
2018
 
2017
U.S. federal statutory tax rate
(21.0
)%
 
(35.0
)%
State income taxes, net of federal benefit
(37.0
)
 
(2.2
)
Non-U.S. income taxed at different rates
102.0

 
0.5

Reduction in tax benefit related to stock-based awards
(217.7
)
 
6.2

Non-deductible expenses
(44.2
)
 
(0.7
)
Research and development credit
132.1

 
1.1

Other
(15.1
)
 
—

Effective income tax rate
(100.9
)%
 
(30.1
)%