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Income Taxes - Net loss and the effective income tax rate (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Reconciliation of the effect of applying the federal statutory rate to the net loss and the effective income tax rate    
Statutory federal income tax rate 21.00% 21.00%
State tax, net of federal benefit 5.50% 6.30%
Permanent differences (0.60%) (1.50%)
Federal research and development credits 5.60% 4.50%
State research and development credits 0.40% 0.60%
Uncertain tax positions (0.60%) (1.00%)
Other differences 0.70% (2.60%)
Change in valuation allowance (31.10%) (27.30%)
Effective income tax rate 0.90% 0.00%