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Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2016
Income Statement [Abstract] |  |  |
Grant income | $ 1,407 | $ 1,693 | $ 1,212
Operating expenses: |  |  |
Research and development | (36,150) | (16,012) | (10,436)
General and administrative | (22,790) | (9,099) | (5,152)
Total operating expenses, net | (57,533) | (23,418) | (14,376)
Other income (expense): |  |  |
Interest income | 1,532 | 84 | 75
Other income (expense) | 3,970 | (46) | (26)
Total other income, net | 5,502 | 38 | 49
Net loss before income tax | (52,031) | (23,380) | (14,327)
Income tax benefit | 7,280 | 3,653 | 1,777
Net loss attributable to ordinary shareholders | (44,751) | (19,727) | (12,550)
Other comprehensive (loss) income: |  |  |
Foreign currency exchange translation adjustment | (6,071) | 802 | (2,942)
Total comprehensive loss | $ (50,822) | $ (18,925) | $ (15,492)
Basic and diluted net loss per ordinary share (usd per share) | $ (1.42) | $ (1.43) | $ (1.26)
Weighted-average basic and diluted ordinary shares (shares) | 31,557,034 | 13,783,222 | 9,933,399

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