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v3.10.0.1

Consolidated Statement of Cash Flows - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2016
Cash flows from operating activities: |  |  |  |  |
Net loss | $ (20,648,000) | $ (7,524,000) | $ (44,751,000) | $ (19,727,000) | $ (12,550,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |
Depreciation | 645,000 |  | 1,709,000 | 1,009,000 | 478,000
Loss on disposal of fixed and intangible assets | 394,000 |  | 8,000 | 0 | 0
Non-cash share-based compensation | 3,393,000 |  | 6,765,000 | 3,153,000 | 2,257,000
Non-cash consideration for licenses | 0 |  | 0 | 0 | 1,199,000
Changes in operating assets and liabilities |  |  |  |  |
Prepaid expenses and other current assets | (3,521,000) |  | (7,132,000) | (2,317,000) | (2,048,000)
Long-term deposits | (1,285,000) |  | 0 | 0 | 0
Accounts payable | (723,000) |  | 838,000 | 434,000 | 507,000
Accrued expenses and other liabilities | 1,960,000 |  | 11,026,000 | 1,088,000 | 308,000
Net cash used in operating activities | (19,785,000) | (8,797,000) | (31,537,000) | (16,360,000) | (9,849,000)
Cash flows from investing activities: |  |  |  |  |
Purchases of property and equipment | (4,422,000) |  | (9,119,000) | (2,876,000) | (1,855,000)
Purchase of intangible assets | 0 |  | (412,000) | 0 | 0
Net cash used in investing activities | (4,422,000) | (764,000) | (9,531,000) | (2,876,000) | (1,855,000)
Cash flows from financing activities: |  |  |  |  |
Proceeds of issuance of ordinary shares, net of issuance costs | 0 |  | 156,920,000 | 127,686,000 | 32,222,000
Net cash provided by financing activities | 0 | 433,000 | 156,920,000 | 127,686,000 | 32,222,000
Effect of exchange rate changes on cash and restricted cash | (5,327,000) |  | (5,833,000) | 561,000 | (2,662,000)
Net (decrease) / increase in cash and restricted cash | (29,534,000) |  | 110,019,000 | 109,011,000 | 17,856,000
Cash and restricted cash, beginning of period | 247,089,000 | 137,070,000 | 137,070,000 | 28,059,000 | 10,203,000
Cash and restricted cash, end of period | 217,555,000 |  | 247,089,000 | 137,070,000 | 28,059,000
Supplemental Cash Flow Information |  |  |  |  |
Property and equipment purchases included in accounts payable and accrued expenses | 3,343,000 |  | 328,000 | 0 | 0
Reconciliation of cash and restricted cash reported within the consolidated balance sheets: |  |  |  |  |
Cash |  | 128,984,000 |  |  |
Total cash and restricted cash | $ 247,089,000 | $ 137,070,000 | $ 137,070,000 | $ 28,059,000 | $ 10,203,000

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