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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2016
Income Statement [Abstract]        
Grant income $ 296 $ 1,407 $ 1,693 $ 1,212
Operating expenses:        
Research and development (17,713) (36,150) (16,012) (10,436)
General and administrative (7,593) (22,790) (9,099) (5,152)
Total operating expenses, net (25,010) (57,533) (23,418) (14,376)
Other income (expense):        
Interest income 660 1,532 84 75
Other income (expense) 1,097 3,970 (46) (26)
Total other income, net 1,757 5,502 38 49
Net loss before income tax (23,253) (52,031) (23,380) (14,327)
Income tax benefit 2,605 7,280 3,653 1,777
Net loss attributable to ordinary shareholders (20,648) (44,751) (19,727) (12,550)
Other comprehensive (loss) income:        
Foreign currency exchange translation adjustment (5,568) (6,071) 802 (2,942)
Total comprehensive loss $ (26,216) $ (50,822) $ (18,925) $ (15,492)
Basic and diluted net loss per ordinary share (usd per share) $ (0.52) $ (1.42) $ (1.43) $ (1.26)
Weighted-average basic and diluted ordinary shares (shares) 39,366,634 31,557,034 13,783,222 9,933,399