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Consolidated Statement of Cash Flows - USD ($)
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2016
Cash flows from operating activities:          
Net loss $ (20,648,000) $ (7,524,000) $ (44,751,000) $ (19,727,000) $ (12,550,000)
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation 645,000   1,709,000 1,009,000 478,000
Loss on disposal of fixed and intangible assets 394,000   8,000 0 0
Non-cash share-based compensation 3,393,000   6,765,000 3,153,000 2,257,000
Non-cash consideration for licenses 0   0 0 1,199,000
Changes in operating assets and liabilities          
Prepaid expenses and other current assets (3,521,000)   (7,132,000) (2,317,000) (2,048,000)
Long-term deposits (1,285,000)   0 0 0
Accounts payable (723,000)   838,000 434,000 507,000
Accrued expenses and other liabilities 1,960,000   11,026,000 1,088,000 308,000
Net cash used in operating activities (19,785,000) (8,797,000) (31,537,000) (16,360,000) (9,849,000)
Cash flows from investing activities:          
Purchases of property and equipment (4,422,000)   (9,119,000) (2,876,000) (1,855,000)
Purchase of intangible assets 0   (412,000) 0 0
Net cash used in investing activities (4,422,000) (764,000) (9,531,000) (2,876,000) (1,855,000)
Cash flows from financing activities:          
Proceeds of issuance of ordinary shares, net of issuance costs 0   156,920,000 127,686,000 32,222,000
Net cash provided by financing activities 0 433,000 156,920,000 127,686,000 32,222,000
Effect of exchange rate changes on cash and restricted cash (5,327,000)   (5,833,000) 561,000 (2,662,000)
Net (decrease) / increase in cash and restricted cash (29,534,000)   110,019,000 109,011,000 17,856,000
Cash and restricted cash, beginning of period 247,089,000 137,070,000 137,070,000 28,059,000 10,203,000
Cash and restricted cash, end of period 217,555,000   247,089,000 137,070,000 28,059,000
Supplemental Cash Flow Information          
Property and equipment purchases included in accounts payable and accrued expenses 3,343,000   328,000 0 0
Reconciliation of cash and restricted cash reported within the consolidated balance sheets:          
Cash   128,984,000      
Total cash and restricted cash $ 247,089,000 $ 137,070,000 $ 137,070,000 $ 28,059,000 $ 10,203,000