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Selected Financial Data for the Three Months Ended December 31, 2017 (Details) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2015
Results of Operations            
Grant income $ 296 $ 231 $ 1,407 $ 1,693 $ 1,212  
Operating expenses:            
Research and development (17,713) (5,564) (36,150) (16,012) (10,436)  
General and administrative (7,593) (3,084) (22,790) (9,099) (5,152)  
Total operating expenses, net (25,010) (8,417) (57,533) (23,418) (14,376)  
Other income (expense):            
Interest income 660 181 1,532 84 75  
Other income (expense) 1,097 (685) 3,970 (46) (26)  
Total other income, net 1,757 (504) 5,502 38 49  
Net loss before income tax (23,253) (8,921) (52,031) (23,380) (14,327)  
Income tax benefit 2,605 1,397 7,280 3,653 1,777  
Net loss attributable to ordinary shareholders (20,648) (7,524) (44,751) (19,727) (12,550)  
Cash Flows            
Net cash used in operating activities (19,785) (8,797) (31,537) (16,360) (9,849)  
Net cash used in investing activities (4,422) (764) (9,531) (2,876) (1,855)  
Net cash provided by financing activities 0 433 156,920 127,686 32,222  
Effect of exchange rate changes on cash   1,042        
Net decrease in cash   (8,086)        
Balance Sheet Data            
Cash 217,450 128,984 246,984 137,070 28,059  
Working capital   131,576        
Net assets   137,515        
Total assets 254,210 142,715 273,205 148,662    
Ordinary shares   1        
Additional paid-in capital 361,311 195,644 357,918 194,351    
Total shareholders' equity $ 232,642 $ 137,515 $ 255,465 $ 142,601 $ 30,687 $ 10,501