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Consolidated Statement of Cash Flows - USD ($) | 3 Months Ended | 12 Months Ended | 15 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Dec. 31, 2018 | Dec. 31, 2019 | Sep. 30, 2018 | Sep. 30, 2017 | Dec. 31, 2017 | Dec. 31, 2019 | Dec. 31, 2018 | Sep. 30, 2018 | Sep. 30, 2017
Cash flows from operating activities: |  |  |  |  |  |  |  |  |
Net loss | $ (20,648,000) | $ (123,849,000) | $ (44,751,000) | $ (19,727,000) | $ (19,727,000) |  |  |  |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |  |  |
Depreciation | 645,000 | 4,611,000 | 1,709,000 | 1,009,000 |  |  |  |  |
Loss on disposal of fixed assets and intangible assets | 394,000 | 43,000 | 8,000 | 0 |  |  |  |  |
Non-cash share-based compensation (net of amount capitalized) | 3,393,000 | 30,212,000 | 6,765,000 | 3,153,000 |  |  |  |  |
Loss on impairment of leasehold improvements | 0 | 4,102,000 | 0 | 0 |  |  |  |  |
Deferred income tax | 0 | (399,000) | 0 | 0 |  |  |  |  |
Changes in operating assets and liabilities |  |  |  |  |  |  |  |  |
Prepaid expenses and other current assets | (3,521,000) | (21,008,000) | (7,132,000) | (2,317,000) |  |  |  |  |
Long-term deposits | (1,285,000) | (702,000) | 0 | 0 |  |  |  |  |
Right of use asset, net |  | 2,551,000 |  |  |  |  |  |  |
Accounts payable | (723,000) | (1,451,000) | 838,000 | 434,000 |  |  |  |  |
Accrued expenses and other liabilities | 1,960,000 | 4,958,000 | 11,026,000 | 1,088,000 |  |  |  |  |
Lease liabilities |  | (552,000) |  |  |  |  |  |  |
Net cash used in operating activities | (19,785,000) | (101,484,000) | (31,537,000) | (16,360,000) |  |  |  |  |
Cash flows from investing activities: |  |  |  |  |  |  |  |  |
Purchases of property and equipment | (4,422,000) | (18,341,000) | (9,119,000) | (2,876,000) |  |  |  |  |
Purchase of intangible assets | 0 | (327,000) | (412,000) | 0 |  |  |  |  |
Net cash used in investing activities | (4,422,000) | (18,668,000) | (9,531,000) | (2,876,000) |  |  |  |  |
Cash flows from financing activities: |  |  |  |  |  |  |  |  |
Proceeds of issuance of ordinary shares, net of issuance costs | 0 | 108,863,000 | 156,920,000 | 127,686,000 |  |  |  |  |
Net cash provided by financing activities | 0 | 108,863,000 | 156,920,000 | 127,686,000 |  |  |  |  |
Effect of exchange rate changes on cash | (5,327,000) | 5,164,000 | (5,833,000) | 561,000 |  |  |  |  |
Net increase in cash | (29,534,000) | (6,125,000) | 110,019,000 | 109,011,000 |  |  |  |  |
Cash and restricted cash, beginning of period | 247,089,000 | 217,555,000 | 137,070,000 | 28,059,000 | 28,059,000 |  |  |  |
Cash and restricted cash, end of period | 217,555,000 | 211,430,000 | 247,089,000 | 137,070,000 |  |  |  |  |
Supplemental non-cash flow information |  |  |  |  |  |  |  |  |
Cash paid for taxes | 0 | 1,535,000 | 0 | 0 |  |  |  |  |
Property and equipment purchases included in accounts payable or accrued | 3,343,000 | 2,818,000 | 328,000 | 0 |  |  |  |  |
Reduction in right of use asset |  | 1,919,000 |  |  |  |  |  |  |
Capitalized share-based compensation | 0 | 174,000 | 0 | 0 |  |  |  |  |
Reconciliation of cash and restricted cash reported within the consolidated balance sheets |  |  |  |  |  |  |  |  |
Cash |  |  |  |  |  | $ 210,643,000 | $ 217,450,000 | $ 246,984,000 | $ 137,070,000
Short-term restricted cash |  |  |  |  |  | 787,000 | 105,000 | 105,000 | 0
Total cash and restricted cash | $ 217,555,000 | $ 211,430,000 | $ 247,089,000 | $ 137,070,000 | $ 28,059,000 | $ 211,430,000 | $ 217,555,000 | $ 247,089,000 | $ 137,070,000

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- Definition Amount of cash restricted as to withdrawal or usage, classified as current. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=98513485&loc=SL98516268-108586 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(1)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118951113&loc=d3e6676-107765 + Details
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- Definition The charge against earnings resulting from the aggregate write down of tangible assets from their carrying value to their fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109226691&loc=d3e2921-110230 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 205 -SubTopic 20 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109222650&loc=d3e1361-107760 + Details
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