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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Operating expenses:        
Research and development $ (33,545) $ (27,310) $ (96,160) $ (76,050)
General and administrative (9,843) (8,605) (25,966) (29,531)
Total operating expenses, net (42,708) (35,618) (120,815) (102,982)
Other income (expense):        
Interest income 37 509 500 2,124
Other (expense) income (2,509) 3,263 2,500 6,659
Total other (expense) income, net (2,472) 3,772 3,000 8,783
Net loss before income tax (45,180) (31,846) (117,815) (94,199)
Income tax benefit 7,865 4,598 18,582 11,294
Net loss attributable to ordinary shareholders (37,315) (27,248) (99,233) (82,905)
Other comprehensive (loss) income:        
Foreign currency exchange translation adjustment 10,915 (9,044) (8,605) (12,865)
Total comprehensive loss $ (26,400) $ (36,292) $ (107,838) $ (95,770)
Basic and diluted net loss per ordinary share (usd per share) $ (0.72) $ (0.61) $ (1.93) $ (1.95)
Weighted-average basic and diluted ordinary shares (shares) 52,093,826 44,505,383 51,339,662 42,547,755
Grant income        
Income Statement [Abstract]        
Revenues $ 438 $ 297 $ 1,069 $ 2,599
Revenues 438 297 1,069 2,599
License revenue        
Income Statement [Abstract]        
Revenues 242 0 242 0
Revenues $ 242 $ 0 $ 242 $ 0