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Share-Based Compensation - Share Based Compensation Allocation (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Share-based Compensation Arrangement by Share-based Payment Award        
Total share-based compensation expense $ 4,245 $ 7,709 $ 15,786 $ 23,940
Research and development        
Share-based Compensation Arrangement by Share-based Payment Award        
Total share-based compensation expense 2,183 4,673 10,450 13,817
General and administrative        
Share-based Compensation Arrangement by Share-based Payment Award        
Total share-based compensation expense 2,062 2,906 5,423 9,993
Capitalized to property and equipment        
Share-based Compensation Arrangement by Share-based Payment Award        
Total share-based compensation expense $ 0 $ 130 $ (87) $ 130