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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities:    
Net loss $ (99,233,000) $ (82,905,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 3,996,000 3,322,000
Share-based compensation (net of amount capitalized) 15,873,000 23,810,000
Gain on lease incentive and modification (1,335,000) 0
Gain on termination of operating lease (160,000) 0
Loss on disposal of property and equipment 0 43,000
Changes in operating assets and liabilities    
Prepaid expenses and other assets, current (12,711,000) (15,841,000)
Prepaid expenses and other assets, non-current (2,650,000) 0
Long-term deposits (455,000) (724,000)
Right of use assets, net 2,593,000 1,870,000
Accounts payable 510,000 362,000
Accrued expenses and other liabilities 4,951,000 1,772,000
Lease liabilities (1,407,000) 74,000
Net cash used in operating activities (90,028,000) (68,217,000)
Cash flows from investing activities:    
Purchases of property and equipment (9,209,000) (16,754,000)
Net cash used in investing activities (9,209,000) (16,754,000)
Cash flows from financing activities:    
Proceeds of issuance of ordinary shares, net of issuance costs 74,023,000 108,829,000
Net cash provided by financing activities 74,023,000 108,829,000
Effect of exchange rate changes on cash and restricted cash (7,735,000) (11,366,000)
Net increase in cash and restricted cash (32,949,000) 12,492,000
Cash and restricted cash, beginning of period 211,430,000 217,555,000
Cash and restricted cash, end of period 178,481,000 230,047,000
Supplemental non-cash flow information    
Property and equipment purchases included in accounts payable and accrued expenses 2,872,000 1,471,000
Right of use assets terminated and obtained in exchange for operating lease liabilities, net 29,062,000 0
Capitalized implementation costs included in accrued expenses 144,000 0
Capitalized share-based compensation (87,000) 130,000
Reconciliation of cash and restricted cash reported within the condensed consolidated balance sheets:    
Total cash and restricted cash $ 178,481,000 $ 230,047,000