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v3.21.1

Nature of the Business (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  |  |  | 1 Months Ended | 3 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
Feb. 12, 2021 | Jan. 27, 2020 | Apr. 15, 2019 | Jun. 22, 2018 | Jan. 31, 2021 | Mar. 31, 2021 | Mar. 31, 2020 | Dec. 31, 2020
Class of Stock |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) |  |  |  |  | 1,718,506 |  |  |
Proceeds of issuance of ordinary shares, net of issuance costs |  |  |  |  | $ 15,300 |  |  |
Net loss |  |  |  |  |  | $ (33,266) | $ (29,873) |
Accumulated deficit |  |  |  |  |  | 412,510 |  | $ 379,244
Cash |  |  |  |  |  | $ 239,012 | $ 243,312 | $ 153,299
Underwriters public offering |  |  |  |  |  |  |  |
Class of Stock |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) |  |  |  |  |  | 1,700,000 |  |
Proceeds of issuance of ordinary shares, net of issuance costs |  | $ 75,000 |  |  |  |  |  |
Ordinary Shares |  |  |  |  |  |  |  |
Class of Stock |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) | 14,285,715 |  |  |  |  |  |  |
Per share price of issuance (usd per share) | $ 7.00 |  |  |  |  |  |  |
Ordinary Shares | IPO |  |  |  |  |  |  |  |
Class of Stock |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) |  |  |  | 10,147,059 |  |  |  |
Per share price of issuance (usd per share) |  |  |  | $ 17.00 |  |  |  |
Proceeds of issuance of ordinary shares, net of issuance costs |  |  |  | $ 156,500 |  |  |  |
Ordinary Shares | Options |  |  |  |  |  |  |  |
Class of Stock |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) | 2,142,857 |  | 630,000 | 1,323,529 |  |  |  |
Ordinary Shares | Underwriters public offering |  |  |  |  |  |  |  |
Class of Stock |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) |  | 7,250,000 | 4,830,000 |  |  |  |  |
Per share price of issuance (usd per share) |  | $ 11.00 | $ 24.00 |  |  |  |  |
Proceeds of issuance of ordinary shares, net of issuance costs | $ 106,900 |  | $ 108,800 |  |  |  |  |

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