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Share-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Stock Options Valuation Assumptions
The assumptions used in the Black-Scholes option pricing model to determine the fair value of the share options granted by the Company during the three months ended March 31, 2021 were as follows:
March 31,
2021
Expected option life (years)
 6.08 years
Risk-free interest rate
0.62% to 0.99%
Expected volatility
81.33% to 81.34%
Expected dividend yield
—%
Stock Option Rollforward
The table below summarizes activity for the three months ended March 31, 2021:
Number of
Options
Weighted-Average Exercise PriceWeighted-Average Remaining Contractual Term (Years)Aggregate Intrinsic Value
Outstanding as of December 31, 20205,611,429 $17.19 8.0$4,262 
Granted1,828,200 8.67 — — 
Exercised(545)0.01 — — 
Canceled or forfeited(557,464)16.68 — — 
Outstanding as of March 31, 20216,881,620 $14.97 8.4$2,194 
Exercisable as of March 31, 20212,954,620 17.20 7.6$2,055 
Vested and expected to vest as of March 31, 20216,881,620 $14.97 8.4$2,194 
Schedule of Nonvested Share Activity
A summary of the changes in the Company’s restricted ordinary shares during the three months ended March 31, 2021 is as follows:
Number of
restricted
shares
Weighted average grant date fair value
Unvested and outstanding at December 31, 202090,383 $4.17 
Granted— — 
Vested(40,124)4.17 
Canceled or forfeited— — 
Unvested and outstanding at March 31, 202150,259 $4.17 
The following is a summary of RSU activity for the 2018 Plan for the three months ended March 31, 2021:
Number of
restricted
shares
Weighted average grant date fair value
Unvested and outstanding at December 31, 2020415,000 $12.09 
Granted1,035,650 8.71 
Vested(21,500)8.12 
Canceled or forfeited(119,250)11.36 
Unvested and outstanding at March 31, 20211,309,900$9.48 
Schedule Share Based Compensation Expense
Share-based compensation expense recorded as research and development expenses, general and administrative expenses, and capitalized to property and equipment is as follows (in thousands):
Three Months Ended March 31,
20212020
Research and development
$(1,654)$4,562 
General and administrative
984 1,627 
Capitalized to property and equipment
— 46 
Total share-based compensation expense
$(670)$6,235