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Nature of the Business (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended
Feb. 12, 2021
Jan. 27, 2020
Apr. 15, 2019
Jun. 22, 2018
Jan. 31, 2021
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2020
Class of Stock                
Number of shares issued in transaction (in shares)         1,718,506      
Proceeds of issuance of ordinary shares, net of issuance costs         $ 15,300      
Net loss           $ (33,266) $ (29,873)  
Accumulated deficit           412,510   $ 379,244
Cash           $ 239,012 $ 243,312 $ 153,299
Underwriters public offering                
Class of Stock                
Number of shares issued in transaction (in shares)           1,700,000    
Proceeds of issuance of ordinary shares, net of issuance costs   $ 75,000            
Ordinary Shares                
Class of Stock                
Number of shares issued in transaction (in shares) 14,285,715              
Per share price of issuance (usd per share) $ 7.00              
Ordinary Shares | IPO                
Class of Stock                
Number of shares issued in transaction (in shares)       10,147,059        
Per share price of issuance (usd per share)       $ 17.00        
Proceeds of issuance of ordinary shares, net of issuance costs       $ 156,500        
Ordinary Shares | Options                
Class of Stock                
Number of shares issued in transaction (in shares) 2,142,857   630,000 1,323,529        
Ordinary Shares | Underwriters public offering                
Class of Stock                
Number of shares issued in transaction (in shares)   7,250,000 4,830,000          
Per share price of issuance (usd per share)   $ 11.00 $ 24.00          
Proceeds of issuance of ordinary shares, net of issuance costs $ 106,900   $ 108,800