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Nature of the Business (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Jun. 17, 2021
Feb. 12, 2021
Jan. 27, 2020
Apr. 15, 2019
Jun. 22, 2018
Oct. 31, 2021
Jan. 31, 2021
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Dec. 31, 2020
Class of Stock                        
Number of shares issued in transaction 2,069,466           1,718,506     3,787,972    
Proceeds of issuance of ordinary shares, net of issuance costs $ 14,300           $ 15,300     $ 29,600    
Net loss               $ (33,991) $ (37,315) (100,430) $ (99,233)  
Accumulated deficit               479,674   479,674   $ 379,244
Cash               $ 173,060 $ 177,695 $ 173,060 $ 177,695 $ 153,299
Subsequent Event                        
Class of Stock                        
Effective income tax rate reconciliation, tax credit, research, amount           $ 25,000            
Underwriters public offering                        
Class of Stock                        
Proceeds of issuance of ordinary shares, net of issuance costs     $ 74,000                  
Ordinary Shares                        
Class of Stock                        
Number of shares issued in transaction   14,285,715                    
Per share price of issuance (usd per share)   $ 7.00                    
Ordinary Shares | IPO                        
Class of Stock                        
Number of shares issued in transaction         10,147,059              
Per share price of issuance (usd per share)         $ 17.00              
Proceeds of issuance of ordinary shares, net of issuance costs         $ 156,500              
Ordinary Shares | Options                        
Class of Stock                        
Number of shares issued in transaction   2,142,857   630,000 1,323,529              
Ordinary Shares | Underwriters public offering                        
Class of Stock                        
Number of shares issued in transaction     7,250,000 4,830,000                
Per share price of issuance (usd per share)     $ 11.00 $ 24.00                
Proceeds of issuance of ordinary shares, net of issuance costs   $ 106,900   $ 108,800