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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Operating expenses:        
Research and development $ (32,292) $ (33,545) $ (95,154) $ (96,160)
General and administrative (8,299) (9,843) (24,274) (25,966)
Loss on disposal of leasehold improvements 0 0 (672) 0
Total operating expenses, net (40,355) (42,708) (117,950) (120,815)
Other income (expense):        
Interest income 28 37 113 500
Other income (expense) 951 (2,509) (59) 2,500
Total other income (expense), net 979 (2,472) 54 3,000
Net loss before income tax (39,376) (45,180) (117,896) (117,815)
Income tax benefit 5,385 7,865 17,466 18,582
Net loss attributable to ordinary shareholders (33,991) (37,315) (100,430) (99,233)
Other comprehensive (loss) income:        
Foreign currency exchange translation adjustment (6,463) 10,915 (3,648) (8,605)
Total comprehensive loss $ (40,454) $ (26,400) $ (104,078) $ (107,838)
Basic net loss per ordinary share (usd per share) $ (0.47) $ (0.72) $ (1.46) $ (1.93)
Diluted net loss per ordinary share (usd per share) $ (0.47) $ (0.72) $ (1.46) $ (1.93)
Weighted-average basic ordinary shares 72,896,362 52,093,826 68,770,962 51,339,662
Weighted-average diluted ordinary shares 72,896,362 52,093,826 68,770,962 51,339,662
Grant income        
Revenues $ 236 $ 438 $ 643 $ 1,069
License revenue        
Revenues $ 0 $ 242 $ 1,507 $ 242