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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities:    
Net loss $ (100,430,000) $ (99,233,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 6,354,000 3,996,000
Share-based compensation (net of amount capitalized) 2,112,000 15,873,000
Gain on lease incentive and modification 0 (1,335,000)
Loss (gain) on termination of operating lease 12,000 (160,000)
Loss on disposal of property and equipment 672,000 0
Deferred income tax 348,000 0
Changes in operating assets and liabilities    
Prepaid expenses and other assets, current (22,749,000) (12,711,000)
Prepaid expenses and other assets, non-current 355,000 (2,650,000)
Long-term deposits 811,000 (455,000)
Right of use assets, net 2,824,000 2,593,000
Accounts payable (783,000) 510,000
Accrued expenses and other liabilities 2,883,000 4,951,000
Lease liabilities (1,112,000) (1,407,000)
Net cash used in operating activities (108,703,000) (90,028,000)
Cash flows from investing activities:    
Purchases of property and equipment (7,272,000) (9,209,000)
Net cash used in investing activities (7,272,000) (9,209,000)
Cash flows from financing activities:    
Proceeds of issuance of ordinary shares, net of issuance costs 136,522,000 73,952,000
Proceeds from the exercise of stock options 126,000 71,000
Net cash provided by financing activities 136,648,000 74,023,000
Effect of exchange rate changes on cash and restricted cash (1,488,000) (7,735,000)
Net increase (decrease) in cash and restricted cash 19,185,000 (32,949,000)
Cash and restricted cash, beginning of period 154,085,000 211,430,000
Cash and restricted cash, end of period 173,270,000 178,481,000
Supplemental non-cash flow information    
Property and equipment purchases included in accounts payable and accrued expenses 1,004,000 2,872,000
Right of use assets terminated and obtained in exchange for operating lease liabilities, net 28,517,000 29,062,000
Capitalized implementation costs included in accrued expenses 11,000 144,000
Capitalized share-based compensation 0 (87,000)
Reconciliation of cash and restricted cash reported within the condensed consolidated balance sheets:    
Cash 173,060,000 177,695,000
Restricted cash 210,000 786,000
Total cash and restricted cash $ 173,270,000 $ 178,481,000