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Net loss per share | 9 Months Ended
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Sep. 30, 2022
Earnings Per Share [Abstract] |
Net loss per share | Net loss per share Basic and diluted net loss per share attributable to ordinary shareholders was calculated as follows (in thousands, except share and per share amounts):
| Three Months Ended September 30, |  | Nine Months Ended September 30,
| 2022 |  | 2021 |  | 2022 |  | 2021
Numerator |  |  |  |  |  |  |
Net loss | $ | (42,767) |  |  | $ | (33,991) |  |  | $ | (121,888) |  |  | $ | (100,430) |
Net loss attributable to ordinary shareholders - basic and diluted | $ | (42,767) |  |  | $ | (33,991) |  |  | $ | (121,888) |  |  | $ | (100,430) |
Denominator |  |  |  |  |  |  |
Weighted-average number of ordinary shares used in net loss per share - basic and diluted | 91,240,801 |  |  | 72,896,362 |  |  | 91,028,562 |  |  | 68,770,962 |
Net loss per share - basic and diluted | $ | (0.47) |  |  | $ | (0.47) |  |  | $ | (1.34) |  |  | $ | (1.46) |
For all periods presented, outstanding but unvested restricted shares and share options have been excluded from the calculation, because their effects would be anti-dilutive. Therefore, the weighted average shares outstanding used to calculate both basic and diluted loss per share are the same for all periods presented. The following potentially dilutive securities have been excluded from the calculation of diluted net loss per share due to their anti-dilutive effect:
| Three and Nine Months Ended September 30,
| 2022 |  | 2021
Unvested restricted incentive shares and units | 996,927 |  |  | 1,105,300 |
Share options | 10,421,137 |  |  | 6,343,281 |
Warrants | 3,265,306 |  |  | — |
Total potentially dilutive securities | 14,683,370 |  | 7,448,581 |

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