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Net loss per share (Tables) | 9 Months Ended
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Sep. 30, 2022
Earnings Per Share [Abstract] |
Schedule of Earnings Per Share, Basic and Diluted | Basic and diluted net loss per share attributable to ordinary shareholders was calculated as follows (in thousands, except share and per share amounts):
| Three Months Ended September 30, |  | Nine Months Ended September 30,
| 2022 |  | 2021 |  | 2022 |  | 2021
Numerator |  |  |  |  |  |  |
Net loss | $ | (42,767) |  |  | $ | (33,991) |  |  | $ | (121,888) |  |  | $ | (100,430) |
Net loss attributable to ordinary shareholders - basic and diluted | $ | (42,767) |  |  | $ | (33,991) |  |  | $ | (121,888) |  |  | $ | (100,430) |
Denominator |  |  |  |  |  |  |
Weighted-average number of ordinary shares used in net loss per share - basic and diluted | 91,240,801 |  |  | 72,896,362 |  |  | 91,028,562 |  |  | 68,770,962 |
Net loss per share - basic and diluted | $ | (0.47) |  |  | $ | (0.47) |  |  | $ | (1.34) |  |  | $ | (1.46) |
Schedule of Anti-dilutive Securities | The following potentially dilutive securities have been excluded from the calculation of diluted net loss per share due to their anti-dilutive effect:
| Three and Nine Months Ended September 30,
| 2022 |  | 2021
Unvested restricted incentive shares and units | 996,927 |  |  | 1,105,300 |
Share options | 10,421,137 |  |  | 6,343,281 |
Warrants | 3,265,306 |  |  | — |
Total potentially dilutive securities | 14,683,370 |  | 7,448,581 |

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- Definition Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257 + Details
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- Definition Tabular disclosure of an entity's basic and diluted earnings per share calculations, including a reconciliation of numerators and denominators of the basic and diluted per-share computations for income from continuing operations. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=124432515&loc=d3e3550-109257 + Details
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