Net loss per share

9 Months Ended

Sep. 30, 2022

Basic and diluted net loss per share attributable to ordinary shareholders was calculated as follows (in thousands, except share and per share amounts):


	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Numerator
Net loss	$	(42,767)	$	(33,991)	$	(121,888)	$	(100,430)
Net loss attributable to ordinary shareholders - basic and diluted	$	(42,767)	$	(33,991)	$	(121,888)	$	(100,430)

Denominator
Weighted-average number of ordinary shares used in net loss per share - basic and diluted	91,240,801		72,896,362		91,028,562		68,770,962
Net loss per share - basic and diluted	$	(0.47)	$	(0.47)	$	(1.34)	$	(1.46)

For all periods presented, outstanding but unvested restricted shares and share options have been excluded from the calculation, because their effects would be anti-dilutive. Therefore, the weighted average shares outstanding used to calculate both basic and diluted loss per share are the same for all periods presented.

The following potentially dilutive securities have been excluded from the calculation of diluted net loss per share due to their anti-dilutive effect:


	Three and Nine Months Ended September 30,
	2022	2021
Unvested restricted incentive shares and units	996,927	1,105,300
Share options	10,421,137	6,343,281
Warrants	3,265,306	—
Total potentially dilutive securities	14,683,370	7,448,581