Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Current assets:
Cash	$ 163,053	$ 310,338
Restricted cash	315	338
Prepaid expenses and other assets, current	48,943	36,276
Total current assets	212,311	346,952
Non-current assets:
Property and equipment, net	32,474	33,541
Prepaid expenses and other non-current assets	1,718	2,362
Operating lease right-of-use assets	13,235	18,775
Long-term deposits	1,688	2,039
Deferred tax asset	2,396	1,826
Intangible assets, net	8	65
Total assets	263,830	405,560
Current liabilities:
Accounts payable	334	431
Accrued expenses and other liabilities	3,815	23,667
Operating lease liabilities	34,669	4,453
Total current liabilities	38,818	28,551
Non-current liabilities:
Operating lease liabilities, net of current portion	11,310	16,545
Liability related to sale of future royalties and sales milestones, net	52,443	47,016
Other long-term payables	105	128
Total liabilities	102,676	92,240
Commitments and contingencies
Shareholders' equity:
Additional paid-in capital	851,824	843,108
Accumulated other comprehensive loss	(47,564)	(8,570)
Accumulated deficit	(643,228)	(521,340)
Total shareholders' equity	161,154	313,320
Total liabilities and shareholders' equity	263,830	405,560
Ordinary shares
Shareholders' equity:
Share value	$ 4	$ 4
Shares outstanding	91,132,356	90,907,830
Shares issued	91,132,356	90,907,830
Deferred shares
Shareholders' equity:
Share value	$ 0	$ 0
Shares outstanding	34,425	34,425
Shares issued	34,425	34,425
Deferred B Shares
Shareholders' equity:
Share value	$ 118	$ 118
Shares outstanding	88,893,548	88,893,548
Shares issued	88,893,548	88,893,548
Deferred C Shares
Shareholders' equity:
Share value	$ 0	$ 0
Shares outstanding	1	1
Shares issued	1	1

Carrying value as of the balance sheet date of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

- Definition

Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).