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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Operating expenses:        
Research and development $ (37,632) $ (32,292) $ (109,806) $ (95,154)
General and administrative (8,231) (8,299) (24,487) (24,274)
Loss on disposal of leasehold improvements 0 0 0 (672)
Total operating expenses, net (43,494) (40,355) (131,758) (117,950)
Other (expense) income:        
Other (expense) income, net (3,740) 951 (4,214) (59)
Interest income 165 28 282 113
Interest expense (1,850) 0 (5,448) 0
Total other (expense) income, net (5,425) 979 (9,380) 54
Net loss before income tax (48,919) (39,376) (141,138) (117,896)
Income tax benefit 6,152 5,385 19,250 17,466
Net loss attributable to ordinary shareholders (42,767) (33,991) (121,888) (100,430)
Other comprehensive loss:        
Foreign currency exchange translation adjustment (14,054) (6,463) (38,994) (3,648)
Total comprehensive loss $ (56,821) $ (40,454) $ (160,882) $ (104,078)
Basic net loss per ordinary share (in usd per share) $ (0.47) $ (0.47) $ (1.34) $ (1.46)
Diluted net loss per ordinary share (in usd per share) $ (0.47) $ (0.47) $ (1.34) $ (1.46)
Weighted-average basic ordinary shares (in shares) 91,240,801 72,896,362 91,028,562 68,770,962
Weighted-average diluted ordinary shares (in shares) 91,240,801 72,896,362 91,028,562 68,770,962
Grant income        
Revenues $ 0 $ 236 $ 166 $ 643
License revenue        
Revenues $ 2,369 $ 0 $ 2,369 $ 1,507