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Condensed Consolidated Statements of Shareholders’ Equity (Unaudited) - USD ($)
$ in Thousands
Total
Ordinary Shares
Deferred Shares
Deferred B Shares
Deferred C Shares
Common shares
Ordinary Shares
Common shares
Deferred Shares
Common shares
Deferred B Shares
Common shares
Deferred C Shares
Additional Paid in Capital
Accumulated other comprehensive loss
Accumulated deficit
Beginning balance (in shares) at Dec. 31, 2020           52,346,231 34,425 88,893,548 1      
Beginning balance at Dec. 31, 2020 $ 210,032         $ 3 $ 0 $ 118 $ 0 $ 595,016 $ (5,861) $ (379,244)
Stockholders' Equity                        
Issuance of ordinary shares, net of issuance costs (in shares)           20,216,544            
Issuance of ordinary shares, net of issuance costs 136,538                 136,538    
Share-based compensation expense 2,112                 2,112    
Issuance of vested restricted stock units (in shares)           163,375            
Issuance of vested restricted stock units 0                      
Exercise of share options (in shares)           192,844            
Exercise of share options 126                 126    
Unrealized loss on foreign currency translation (3,648)                   (3,648)  
Net loss (100,430)                     (100,430)
Ending balance (in shares) at Sep. 30, 2021           72,918,994 34,425 88,893,548 1      
Ending balance at Sep. 30, 2021 244,730         $ 3 $ 0 $ 118 $ 0 733,792 (9,509) (479,674)
Beginning balance (in shares) at Jun. 30, 2021           72,742,582 34,425 88,893,548 1      
Beginning balance at Jun. 30, 2021 283,682         $ 3 $ 0 $ 118 $ 0 732,290 (3,046) (445,683)
Stockholders' Equity                        
Share-based compensation expense 1,502                 1,502    
Issuance of vested restricted stock units (in shares)           141,875            
Issuance of vested restricted stock units 0                      
Exercise of share options (in shares)           34,537            
Exercise of share options 0                      
Unrealized loss on foreign currency translation (6,463)                   (6,463)  
Net loss (33,991)                     (33,991)
Ending balance (in shares) at Sep. 30, 2021           72,918,994 34,425 88,893,548 1      
Ending balance at Sep. 30, 2021 244,730         $ 3 $ 0 $ 118 $ 0 733,792 (9,509) (479,674)
Beginning balance (in shares) at Dec. 31, 2021   90,907,830 34,425 88,893,548 1 90,907,830 34,425 88,893,548 1      
Beginning balance at Dec. 31, 2021 313,320         $ 4 $ 0 $ 118 $ 0 843,108 (8,570) (521,340)
Stockholders' Equity                        
Share-based compensation expense 8,599                 8,599    
Issuance of vested restricted stock units (in shares)           76,804            
Issuance of vested restricted stock units 0                      
Exercise of share options (in shares)           147,722            
Exercise of share options 117                 117    
Unrealized loss on foreign currency translation (38,994)                   (38,994)  
Net loss (121,888)                     (121,888)
Ending balance (in shares) at Sep. 30, 2022   91,132,356 34,425 88,893,548 1 91,132,356 34,425 88,893,548 1      
Ending balance at Sep. 30, 2022 161,154         $ 4 $ 0 $ 118 $ 0 851,824 (47,564) (643,228)
Beginning balance (in shares) at Jun. 30, 2022           90,909,783 34,425 88,893,548 1      
Beginning balance at Jun. 30, 2022 214,521         $ 4 $ 0 $ 118 $ 0 848,370 (33,510) (600,461)
Stockholders' Equity                        
Share-based compensation expense 3,337                 3,337    
Issuance of vested restricted stock units (in shares)           76,804            
Issuance of vested restricted stock units 0                      
Exercise of share options (in shares)           145,769            
Exercise of share options 117                 117    
Unrealized loss on foreign currency translation (14,054)                   (14,054)  
Net loss (42,767)                     (42,767)
Ending balance (in shares) at Sep. 30, 2022   91,132,356 34,425 88,893,548 1 91,132,356 34,425 88,893,548 1      
Ending balance at Sep. 30, 2022 $ 161,154         $ 4 $ 0 $ 118 $ 0 $ 851,824 $ (47,564) $ (643,228)