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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Cash flows from operating activities:    
Net loss $ (121,888) $ (100,430)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 5,773 6,354
Non-cash share-based compensation 8,599 2,112
Non-cash interest expense 5,427 0
Foreign exchange differences 10,537 0
Loss on termination of operating lease 0 12
Loss on disposal of fixed assets and intangible assets 0 672
Deferred income tax (587) 348
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (20,809) (22,749)
Prepaid expenses and other non-current assets 301 355
Long-term deposits (5) 811
Accounts payable (87) (783)
Accrued expenses and other liabilities 15,469 2,883
Current and non-current operating lease liabilities, net of operating lease right of use assets (472) 1,712
Net cash used in operating activities (97,742) (108,703)
Cash flows from investing activities:    
Purchases of property and equipment (10,208) (7,272)
Net cash used in investing activities (10,208) (7,272)
Cash flows from financing activities:    
Proceeds of issuance of ordinary shares 0 136,522
Proceeds from the exercise of share options 117 126
Payments of equity issuance costs (16) 0
Net cash provided by financing activities 101 136,648
Effect of exchange rate changes on cash and restricted cash (39,459) (1,488)
Net (decrease) increase in cash and restricted cash (147,308) 19,185
Cash and restricted cash, beginning of period 310,676 154,085
Cash and restricted cash, end of period 163,368 173,270
Supplemental non-cash flow information    
Property and equipment purchases included in accounts payable and accrued expenses 1,219 1,004
Right of use assets obtained in exchange for operating lease liabilities 57 28,517
Capitalized implementation costs included in accrued expenses 31 11
Reconciliation of cash and restricted cash reported within the condensed consolidated balance sheets:    
Cash 163,053 173,060
Restricted cash 315 210
Total cash and restricted cash $ 163,368 $ 173,270