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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Operating expenses:        
Research and development $ (37,237) $ (37,632) $ (105,323) $ (109,806)
General and administrative (10,611) (8,231) (31,017) (24,487)
Loss on disposal of property and equipment 0 0 (3,791) 0
Impairment of operating lease right-of-use assets and related property and equipment (382) 0 (382) 0
Total operating expenses, net (47,824) (43,494) (138,815) (131,758)
Other income (expense):        
Other expenses, net (1,597) (3,740) (333) (4,214)
Interest income 3,646 165 10,495 282
Interest expense (5,014) (1,850) (14,939) (5,448)
Total other expense, net (2,965) (5,425) (4,777) (9,380)
Net loss before income tax (50,789) (48,919) (143,592) (141,138)
Income tax benefit 4,940 6,152 12,380 19,250
Net loss attributable to ordinary shareholders (45,849) (42,767) (131,212) (121,888)
Other comprehensive (loss) income:        
Foreign currency exchange translation adjustment (5,837) (14,054) 5,104 (38,994)
Total comprehensive loss $ (51,686) $ (56,821) $ (126,108) $ (160,882)
Basic net loss per ordinary share (in usd per share) $ (0.26) $ (0.47) $ (0.75) $ (1.34)
Diluted net loss per ordinary share (in usd per share) $ (0.26) $ (0.47) $ (0.75) $ (1.34)
Weighted-average basic ordinary shares (in shares) 173,984,101 91,240,801 173,890,666 91,028,562
Weighted-average diluted ordinary shares (in shares) 173,984,101 91,240,801 173,890,666 91,028,562
Grant income        
Revenues $ 0 $ 0 $ 0 $ 166
License revenue        
Revenues $ 406 $ 2,369 $ 1,698 $ 2,369