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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Dec. 31, 2022
Cash flows from operating activities:          
Net loss $ (45,849) $ (42,767) $ (131,212) $ (121,888)  
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation and amortization     4,790 5,773  
Share-based compensation net of amounts capitalized     7,929 8,599  
Interest expense accrued on liability related to future royalties and sales milestones, net 5,000 1,800 14,878 5,427  
Foreign exchange differences     (366) 10,537  
Loss on termination of operating lease     95 0  
Loss on disposal of property and equipment     3,812 0  
Impairment of operating lease right-of-use assets and related property and equipment 382 0 382 0  
Deferred income tax     (520) (587)  
Changes in operating assets and liabilities:          
Prepaid expenses and other current assets     (7,655) (20,809)  
Non-current prepaid expenses and other non-current assets     1,932 301  
Long-term deposits     937 (5)  
Accounts payable     69 (87)  
Accrued expenses and other liabilities     (6,823) 15,469  
Current and non-current operating lease liabilities, net of operating lease right of use assets     (9,002) (472)  
Net cash used in operating activities     (120,754) (97,742)  
Cash flows from investing activities:          
Purchases of property and equipment     (9,509) (10,208)  
Net cash used in investing activities     (9,509) (10,208)  
Cash flows from financing activities:          
Proceeds from the exercise of share options     4 117  
Payments of equity issuance costs     (910) (16)  
Net cash (used in) provided by financing activities     (906) 101  
Effect of exchange rate changes on cash, cash equivalents and restricted cash     5,257 (39,459)  
Net decrease in cash, cash equivalents and restricted cash     (125,912) (147,308)  
Cash, cash equivalents and restricted cash, beginning of period     382,761 310,676 $ 310,676
Cash, cash equivalents and restricted cash, end of period 256,849 163,368 256,849 163,368 382,761
Supplemental non-cash flow information          
Property and equipment purchases included in accounts payable and accrued expenses     1,389 1,219  
Right-of-use assets obtained in exchange for operating lease liabilities     41,211 57  
Right of use assets terminated and obtained in exchange for operating lease liabilities, net     (1,110) 0  
Capitalized implementation costs included in accrued expenses     74 31  
Capitalized share-based compensation     19 0  
Reconciliation of cash, cash equivalents and restricted cash reported within the condensed consolidated balance sheets:          
Cash and cash equivalents 256,415 163,053 256,415 163,053 382,436
Restricted cash 434 315 434 315 325
Total cash, cash equivalents and restricted cash $ 256,849 $ 163,368 $ 256,849 $ 163,368 $ 382,761