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Stock Incentive Plans - Plan Information and Valuation Assumptions (Details) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Jun. 30, 2015 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Apr. 30, 2015
Stock based compensation |  |  |  |  |
Shares reserved for future issuance (in shares) |  | 2,799,213 | 9,445,451 |  |
Total stock-based compensation expense |  | $ 1,658 | $ 897 | $ 343 |
Vesting period |  | 4 years |  |  |
Cliff period for vesting |  | 1 year |  |  |
Exercisable period |  | 10 years |  |  |
Weighted average of the assumptions used to compute employee stock based compensation |  |  |  |  |
Expected dividend yield (as a percent) |  | 0.00% | 0.00% | 0.00% |
Research and development |  |  |  |  |
Stock based compensation |  |  |  |  |
Total stock-based compensation expense |  | $ 681 | $ 434 | $ 224 |
General and administrative |  |  |  |  |
Stock based compensation |  |  |  |  |
Total stock-based compensation expense |  | $ 977 | $ 463 | $ 119 |
Minimum |  |  |  |  |
Weighted average of the assumptions used to compute employee stock based compensation |  |  |  |  |
Weighted-average expected volatility (as a percent) |  | 73.60% | 75.20% | 75.00% |
Expected term (in years) |  | 6 years 2 months 1 day | 6 years 3 months | 6 years 3 months |
Risk free interest rate (as a percent) |  | 0.92% | 1.71% | 0.92% |
Maximum |  |  |  |  |
Weighted average of the assumptions used to compute employee stock based compensation |  |  |  |  |
Weighted-average expected volatility (as a percent) |  | 86.80% | 83.40% | 81.50% |
Expected term (in years) |  | 10 years | 10 years | 10 years |
Risk free interest rate (as a percent) |  | 2.45% | 3.01% | 2.03% |
2015 Plan |  |  |  |  |
Stock based compensation |  |  |  |  |
Shares reserved for future issuance (in shares) |  | 1,135,784 |  |  |
2015 Plan | Maximum |  |  |  |  |
Stock based compensation |  |  |  |  |
Shares available for grant (in shares) |  | 1,068,287 |  |  |
2008 Plan |  |  |  |  |
Stock based compensation |  |  |  |  |
Shares reserved for future issuance (in shares) |  | 1,421,672 |  |  |
Common stock | 2015 Plan |  |  |  |  |
Stock based compensation |  |  |  |  |
Shares available for grant (in shares) | 182,352 | 1,297,334 |  |  |
Shares available for future issuance (in shares) |  | 833,902 |  |  |
Percentage of outstanding Common Stock available for issuance (as a percent) |  | 4.00% |  |  |
Common stock | 2015 Plan | Annual minimum increase |  |  |  |  |
Stock based compensation |  |  |  |  |
Percentage of outstanding Common Stock available for issuance (as a percent) | 1.00% |  |  |  |
Common stock | 2008 Plan |  |  |  |  |
Stock based compensation |  |  |  |  |
Shares available for grant (in shares) |  |  |  |  | 25,942
Shares available for future issuance (in shares) |  | 0 |  |  |

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F + Details
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- Definition Estimated period over which an employee is required to provide service in exchange for the equity-based payment award, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(iii) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(ii) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The risk-free interest rate assumption that is used in valuing an option on its own shares. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2)(iv) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(3) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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- Definition Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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