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Summary of Significant Accounting Polices - Warrants thru Stock-Based Compensation (Details) - USD ($)
$ / shares in Units, shares in Millions
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2010
Warrants        
Warrants outstanding 0.0 0.1    
Exercise price of warrants (in dollars per share)       $ 1.67
Assets:        
Money market fund $ 62,004,000 $ 13,506,000    
Liabilities:        
Liability 0      
Stock based compensation        
Stock-based compensation expense 1,658,000 897,000 $ 343,000  
Research and development        
Stock based compensation        
Stock-based compensation expense 681,000 434,000 224,000  
General and administrative        
Stock based compensation        
Stock-based compensation expense 977,000 463,000 $ 119,000  
Recurring        
Assets:        
Money market fund 13,506,000 62,004,000    
Total 13,506,000 62,004,000    
Recurring | Level 2        
Liabilities:        
Total 108,000      
Recurring | Level 2 | Warrant Liability        
Liabilities:        
Liability 108,000      
Recurring | Level 3        
Assets:        
Money market fund 13,506,000 62,004,000    
Total 13,506,000 $ 62,004,000    
Liabilities:        
Total 108,000      
Recurring | Level 3 | Warrant Liability        
Liabilities:        
Liability $ 108,000