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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating expenses:      
Research and development $ 23,030 $ 15,686 $ 13,994
General and administrative 8,629 5,995 4,125
Total operating expenses 31,659 21,681 18,119
Loss from operations (31,659) (21,681) (18,119)
Other income (expense):      
Other (expense) income, net 7 3 1
Interest expense (978) (206)  
Total other (expense) income (971) (203) 1
Net loss and comprehensive loss $ (32,630) $ (21,884) $ (18,118)
Net loss per share - basic and diluted (in dollars per share) $ (4.06) $ (51.56) $ (47.80)
Weighted-average common shares outstanding used in net loss per share - basic and diluted (in shares) 8,041,948 424,477 379,025