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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating activities      
Net loss $ (32,630) $ (21,884) $ (18,118)
Reconciliation of net loss to net cash used in operating activities:      
Depreciation and amortization 202 248 320
Stock-based compensation expense 1,658 897 343
Noncash interest expense 293 74  
Changes in operating assets and liabilities:      
Prepaid expenses and other current assets (450) (208) 75
Other assets 2    
Accounts payable 196 481 (129)
Accrued expenses 954 8 1,156
Deferred rent (18) (28) (13)
Net cash used in operating activities (29,793) (20,412) (16,366)
Investing activities      
Purchases of available-for-sale securities   (4,976)  
Sales of available-for-sale-securities   4,976  
Purchases of property and equipment (421) (228) (43)
Net cash used in investing activities (421) (228) (43)
Financing activities      
Proceeds from initial public offering, net of issuance costs 61,744    
Proceeds from issuance of preferred stock, net of issuance costs 12,331   41,422
Proceeds from exercise of common stock options 91 118 27
Proceeds from borrowings 5,000 5,000  
Payments on borrowing (833)    
Debt issuance costs (7) (284)  
Net cash provided by financing activities 78,326 4,834 41,449
Net increase (decrease) in cash and cash equivalents 48,112 (15,806) 25,040
Cash and cash equivalents, beginning of period 14,668 30,474 5,434
Cash and cash equivalents, end of period 62,780 14,668 $ 30,474
Supplemental disclosure of cash flow information      
Cash paid for interest 684 100  
Non-cash financing activities      
Warrants for the purchase of series B preferred stock issued in conjunction with credit facility 107 110  
Initial public offering costs in accounts payable and accrued liabilities (492) $ 492  
Conversion of preferred stock into common stock 92,477    
Reclassification of deferred IPO costs from non-current assets to additional paid-in capital 1,787    
Reclassification of warrant liability to additional paid-in capital $ 206