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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Operating activities    
Net loss $ (9,418) $ (6,500)
Reconciliation of net loss to net cash used in operating activities:    
Depreciation and amortization 92 52
Stock-based compensation expense 548 301
Accretion of discount/premium on investment securities 38  
Noncash interest expense 79 38
Changes in assets and liabilities:    
Prepaid expenses and other current assets (38) (194)
Other assets (2)  
Accounts payable 230 (79)
Accrued expenses (663) (837)
Deferred rent (13) (9)
Net cash used in operating activities (9,147) (7,228)
Investing activities    
Purchases of available-for-sale securities (32,111)  
Sales and maturities of available-for-sale securities 3,332  
Purchases of property and equipment (290) (25)
Net cash used in investing activities (29,069) (25)
Financing activities    
Proceeds from issuance of preferred stock, net of issuance costs   12,331
Proceeds from exercise of common stock options and warrants 87 51
Proceeds from borrowing   5,000
Payments on borrowing (833)  
Deferred initial public offering costs   (487)
Debt issuance costs   (7)
Net cash (used in) provided by financing activities (746) 16,888
Net (decrease) increase in cash and cash equivalents (38,962) 9,635
Cash and cash equivalents, beginning of period 62,780 14,668
Cash and cash equivalents, end of period 23,818 24,303
Supplemental disclosure of cash flow information    
Cash paid for interest 163 94
Non-cash financing activities    
Warrants for the purchase of series B preferred stock issued in conjunction with credit facility   107
Initial public offering costs in accounts payable and accrued liabilities   $ 475
Fixed asset purchases included in accounts payable $ 68