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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Operating activities    
Net loss $ (14,850) $ (18,863)
Reconciliation of net loss to net cash used in operating activities:    
Depreciation and amortization 165 195
Stock-based compensation expense 986 1,065
Accretion of discount/premium on investment securities 25 77
Non-cash interest expense 94 153
Gain on sale of fixed assets (30) (25)
Changes in assets and liabilities:    
Prepaid expenses and other current assets 109 (140)
Accounts payable 650 210
Accrued expenses (952) (622)
Deferred rent 18 (26)
Net cash used in operating activities (13,785) (17,976)
Investing activities    
Purchases of available-for-sale securities   (32,111)
Sales and maturities of available-for-sale securities 14,910 13,503
Purchases of property and equipment (39) (388)
Sale of property and equipment 30 25
Net cash provided by (used in) investing activities 14,901 (18,971)
Financing activities    
Proceeds from at-the-market offering, net of issuance costs 6,301  
Proceeds from exercise of common stock options and warrants 23 111
Payments on borrowing (1,667) (1,666)
Net cash provided by (used in) financing activities 4,657 (1,555)
Net increase (decrease) in cash and cash equivalents 5,773 (38,502)
Cash and cash equivalents, beginning of period 23,596 62,780
Cash and cash equivalents, end of period 29,369 24,278
Supplemental disclosure of cash flow information    
Cash paid for interest $ 195 463
Non-cash financing activities    
Fixed asset purchases included in accounts payable   $ 21