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v3.8.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Operating activities |  |  |
Net loss | $ (27,364) | $ (36,060) | $ (32,630)
Reconciliation of net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 304 | 395 | 202
Stock-based compensation expense | 2,007 | 2,160 | 1,658
Accretion of discount/premium on investment securities | 26 | 148 |
Non-cash interest expense | 155 | 277 | 293
Gain on sale of fixed assets | (30) | (52) |
Changes in assets and liabilities: |  |  |
Prepaid expenses and other current assets | (93) | (229) | (450)
Other assets |  |  | 2
Accounts payable | (632) | 77 | 196
Accrued expenses | (1,215) | 418 | 954
Deferred rent | 6 | 8 | (18)
Net cash used in operating activities | (26,836) | (32,858) | (29,793)
Investing activities |  |  |
Purchases of available-for-sale securities |  | (45,539) |
Sales and maturities of available-for-sale securities | 14,910 | 30,456 |
Purchases of property and equipment | (57) | (459) | (421)
Sale of property and equipment | 30 | 52 |
Net cash provided by (used in) investing activities | 14,883 | (15,490) | (421)
Financing activities |  |  |
Proceeds from initial public offering, net of issuance costs |  |  | 61,744
Proceeds from issuance of preferred stock, net of issuance costs |  |  | 12,331
Proceeds from registered direct offering, net of issuance costs |  | 10,603 |
Proceeds from at-the-market offering, net of issuance costs | 8,036 | 1,391 |
Proceeds from exercise of common stock options and warrants | 23 | 503 | 91
Proceeds from borrowing |  |  | 5,000
Payments on borrowing | (3,333) | (3,333) | (833)
Debt issuance costs |  |  | (7)
Net cash provided by financing activities | 4,726 | 9,164 | 78,326
Net (decrease) increase in cash and cash equivalents | (7,227) | (39,184) | 48,112
Cash and cash equivalents, beginning of period | 23,596 | 62,780 | 14,668
Cash and cash equivalents, end of period | 16,369 | 23,596 | 62,780
Supplemental disclosure of cash flow information |  |  |
Cash paid for interest | $ 327 | $ 582 | 684
Non-cash financing activities |  |  |
Warrants for the purchase of series B preferred stock issued in conjunction with credit facility |  |  | 107
Initial public offering costs in accounts payable and accrued liabilities |  |  | (492)
Reclassification of deferred IPO costs from non-current assets to additional paid-in capital |  |  | 1,787
Reclassification of warrant liability to additional paid-in capital |  |  | $ 206

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