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Organization and Operations - Liquidity and Going Concern (Details) - USD ($) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Jan. 01, 2018 | Aug. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Oct. 31, 2017 | Mar. 31, 2017 | Dec. 31, 2014
Common Stock |  |  |  |  |  |  |  |
Share price (in dollars per share) |  |  | $ 0.001 |  |  |  |  |
Additional common stock issued |  |  | $ 8,036 | $ 11,994 | $ 61,744 |  |  |
Proceeds from registered direct offering, net of issuance costs |  |  |  | 10,603 |  |  |  |
Accumulated deficit |  |  | (171,434) | (144,070) |  |  |  |
Cash and cash equivalents |  |  | $ 16,369 | $ 23,596 | $ 62,780 |  |  | $ 14,668
Common Stock |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Number of shares issued |  |  | 4,804,796 | 3,243,015 | 5,750,000 |  |  |
Additional common stock issued |  |  | $ 5 | $ 3 | $ 5 |  |  |
Common Stock | Cowen |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Percentage of commission payable to underwriter based on proceeds from common stock |  | 3.00% |  |  |  |  |  |
Common Stock | First ATM Program |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Number of shares issued |  |  | 4,804,796 |  |  |  |  |
Share price (in dollars per share) |  |  | $ 1.79 |  |  |  |  |
Additional common stock issued |  |  | $ 8,600 |  |  |  |  |
Net proceeds |  |  | 8,000 |  |  |  |  |
Common Stock | First ATM Program | Cowen |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Aggregate maximum offering amount |  | $ 10,000 |  |  |  |  | $ 8,800 |
Common Stock | Second ATM Program |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Remaining common stock available for sale under offering program |  |  | $ 8,600 |  |  |  |  |
Common Stock | Second ATM Program | Cowen |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Aggregate maximum offering amount |  |  |  |  |  | $ 10,000 |  |
Common Stock | Second ATM Program | Subsequent Events |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Number of shares issued | 5,390,255 |  |  |  |  |  |  |
Share price (in dollars per share) | $ 1.59 |  |  |  |  |  |  |
Additional common stock issued | $ 8,600 |  |  |  |  |  |  |
Net proceeds | $ 8,300 |  |  |  |  |  |  |
Common Stock | Second ATM Program | Subsequent Events | Cowen |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Number of shares issued | 5,390,255 |  |  |  |  |  |  |
Share price (in dollars per share) | $ 1.59 |  |  |  |  |  |  |
Additional common stock issued | $ 8,600 |  |  |  |  |  |  |
Net proceeds | $ 8,300 |  |  |  |  |  |  |
Common Stock | Registered Direct Offering |  |  |  |  |  |  |  |
Common Stock |  |  |  |  |  |  |  |
Number of shares issued |  |  |  | 3,243,015 |  |  |  |
Share price (in dollars per share) |  |  |  | $ 4.04 |  |  |  |
Additional common stock issued |  |  |  | $ 13,100 |  |  |  |
Proceeds from registered direct offering, net of issuance costs |  |  |  | $ 12,000 |  |  |  |

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