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Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Series A Convertible Preferred Stock | Series B Convertible Preferred Stock | Common Stock | Additional Paid-in Capital | Accumulated Deficit | Accumulated Other Comprehensive Loss | Total
--- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2014 | $ 47,898 | $ 32,248 |  |  |  |  |
Balance (in shares) at Dec. 31, 2014 | 68,837,703 | 34,129,571 |  |  |  |  |
Increase (decrease) in Convertible Preferred Stock |  |  |  |  |  |  |
Issuance of series B convertible preferred stock, net of issuance cost of $0.1 million |  | $ 12,331 |  |  |  |  |
Issuance of series B convertible preferred stock, net of issuance cost of $0.1 million (in shares) |  | 13,062,965 |  |  |  |  |
Conversion of convertible preferred stock into common stock | $ (47,898) | $ (44,579) |  |  |  |  |
Conversion of convertible preferred stock into common stock (in shares) | (68,837,703) | (47,192,536) |  |  |  |  |
Balance at Dec. 31, 2014 |  |  | $ 1 | $ 2,326 | $ (75,380) |  | $ (73,053)
Balance (in shares) at Dec. 31, 2014 |  |  | 493,200 |  |  |  |
Increase (Decrease) in Stockholders' Equity (Deficit) |  |  |  |  |  |  |
Issuance of common stock from initial public offering/for registered direct and at-the-market offerings, net of issuance costs of $0.6 million, $1.1 million and $7.3 million for the years 2017, 2016 and 2015 respectively |  |  | $ 5 | 61,739 |  |  | 61,744
Issuance of common stock from initial public offering/for registered direct and at-the-market offerings, net of issuance costs of $0.6 million, $1.1 million and $7.3 million for the years 2017, 2016 and 2015 respectively (in shares) |  |  | 5,750,000 |  |  |  |
Conversion of convertible preferred stock into common stock |  |  | $ 9 | 92,468 |  |  | 92,477
Conversion of convertible preferred stock into common stock (in shares) |  |  | 9,029,549 |  |  |  |
Conversion of series B preferred stock warrants into warrants for the purchase of common stock |  |  |  | 206 |  |  | 206
Proceeds from exercises of common stock options |  |  |  | 91 |  |  | 91
Proceeds from exercises of common stock options (in shares) |  |  | 40,548 |  |  |  |
Stock-based compensation expense |  |  |  | 1,658 |  |  | 1,658
Net loss |  |  |  |  | (32,630) |  | (32,630)
Balance at Dec. 31, 2015 |  |  | $ 15 | 158,488 | (108,010) |  | 50,493
Balance (in shares) at Dec. 31, 2015 |  |  | 15,313,297 |  |  |  |
Increase (Decrease) in Stockholders' Equity (Deficit) |  |  |  |  |  |  |
Issuance of common stock from initial public offering/for registered direct and at-the-market offerings, net of issuance costs of $0.6 million, $1.1 million and $7.3 million for the years 2017, 2016 and 2015 respectively |  |  | $ 3 | 11,991 |  |  | 11,994
Issuance of common stock from initial public offering/for registered direct and at-the-market offerings, net of issuance costs of $0.6 million, $1.1 million and $7.3 million for the years 2017, 2016 and 2015 respectively (in shares) |  |  | 3,243,015 |  |  |  |
Proceeds from exercises of common stock options and warrants |  |  | $ 1 | 502 |  |  | 503
Proceeds from exercises of common stock options and warrants (in shares) |  |  | 261,260 |  |  |  |
Stock-based compensation expense |  |  |  | 2,160 |  |  | 2,160
Unrealized losses on short-term investments |  |  |  |  |  | $ (4) | (4)
Net loss |  |  |  |  | (36,060) |  | (36,060)
Balance at Dec. 31, 2016 |  |  | $ 19 | 173,141 | (144,070) | (4) | $ 29,086
Balance (in shares) at Dec. 31, 2016 |  |  | 18,817,572 |  |  |  | 18,817,572
Increase (Decrease) in Stockholders' Equity (Deficit) |  |  |  |  |  |  |
Issuance of common stock from initial public offering/for registered direct and at-the-market offerings, net of issuance costs of $0.6 million, $1.1 million and $7.3 million for the years 2017, 2016 and 2015 respectively |  |  | $ 5 | 8,031 |  |  | $ 8,036
Issuance of common stock from initial public offering/for registered direct and at-the-market offerings, net of issuance costs of $0.6 million, $1.1 million and $7.3 million for the years 2017, 2016 and 2015 respectively (in shares) |  |  | 4,804,796 |  |  |  |
Proceeds from exercises of common stock options |  |  |  | 23 |  |  | $ 23
Proceeds from exercises of common stock options (in shares) |  |  | 22,879 |  |  |  | 22,879
Stock-based compensation expense |  |  |  | 2,007 |  |  | $ 2,007
Realized gain on short-term investments |  |  |  |  |  | $ 4 | 4
Net loss |  |  |  |  | (27,364) |  | (27,364)
Balance at Dec. 31, 2017 |  |  | $ 24 | $ 183,202 | $ (171,434) |  | $ 11,792
Balance (in shares) at Dec. 31, 2017 |  |  | 23,645,247 |  |  |  | 23,645,247

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Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant

X
- Definition The number of securities classified as temporary equity that have been issued and are held by the entity's shareholders. Securities outstanding equals securities issued minus securities held in treasury. Temporary equity is a security with redemption features that are outside the control of the issuer, is not classified as an asset or liability in conformity with GAAP, and is not mandatorily redeemable. Includes any type of security that is redeemable at a fixed or determinable price or on a fixed or determinable date or dates, is redeemable at the option of the holder, or has conditions for redemption which are not solely within the control of the issuer. If convertible, the issuer does not control the actions or events necessary to issue the maximum number of shares that could be required to be delivered under the conversion option if the holder exercises the option to convert the stock to another class of equity. If the security is a warrant or a rights issue, the warrant or rights issue is considered to be temporary equity if the issuer cannot demonstrate that it would be able to deliver upon the exercise of the option by the holder in all cases. Includes stock with put option held by ESOP and stock redeemable by holder only in the event of a change in control of the issuer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(27)(b)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
Name: | us-gaap_TemporaryEquitySharesOutstanding
Namespace Prefix: | us-gaap_
Data Type: | xbrli:sharesItemType
Balance Type: | na
Period Type: | instant

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- Definition Value of new stock classified as temporary equity issued during the period. + References No definition available. + Details
Name: | us-gaap_TemporaryEquityStockIssuedDuringPeriodValueNewIssues
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration