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Quarterly Financial Information (Unaudited) (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Quarterly Financial Information (Unaudited) |  |  |  |  |  |  |  |  |  |  |
Revenue | $ 250 | $ 250 |  |  |  |  |  |  | $ 500 |  |
Operating expenses | 5,712 | 7,202 | $ 6,919 | $ 7,761 | $ 8,673 | $ 8,283 | $ 9,396 | $ 9,206 | 27,594 | $ 35,558 | $ 31,659
Net loss | $ (5,497) | $ (7,017) | $ (6,974) | $ (7,876) | $ (8,778) | $ (8,419) | $ (9,445) | $ (9,418) | $ (27,094) | $ (35,558) | $ (31,659)
Net loss per share: |  |  |  |  |  |  |  |  |  |  |
Basic and Diluted (in dollars per share) | $ (0.24) | $ (0.31) | $ (0.32) | $ (0.41) | $ (0.47) | $ (0.54) | $ (0.61) | $ (0.61) | $ (1.26) | $ (2.22) | $ (4.06)
Weighted-average common shares outstanding used in net loss per share: |  |  |  |  |  |  |  |  |  |  |
Basic and Diluted (in shares) | 23,218,476 | 22,563,174 | 21,796,194 | 19,093,273 | 18,699,480 | 15,512,608 | 15,373,964 | 15,335,516 | 21,681,534 | 16,230,190 | 8,041,948

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- Definition The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. + References No definition available. + Details
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