Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Consolidated Statements of Operations
Revenue	$ 500
Operating expenses:
Research and development	18,682	$ 25,450	$ 23,030
General and administrative	8,912	10,108	8,629
Total operating expenses	27,594	35,558	31,659
Loss from operations	(27,094)	(35,558)	(31,659)
Other (expense) income:
Interest expense	(462)	(837)	(978)
Interest and investment income	160	242
Other income, net	32	93	7
Total other expense, net	(270)	(502)	(971)
Net loss	$ (27,364)	$ (36,060)	$ (32,630)
Net loss per share - basic and diluted (in dollars per share)	$ (1.26)	$ (2.22)	$ (4.06)
Weighted-average common shares outstanding used in net loss per share - basic and diluted (in shares)	21,681,534	16,230,190	8,041,948

The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

No definition available.