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Organization and Operations - Liquidity and Going Concern (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	3 Months Ended
	Oct. 31, 2017	Mar. 31, 2018	Dec. 31, 2017	Mar. 31, 2017
Common Stock
Accumulated deficit		$ (179,086)	$ (171,434)
Cash and cash equivalents		$ 17,030	$ 16,369	$ 31,795
Common Stock | Cowen
Common Stock
Percentage of commission paid to underwriter based on proceeds from common stock	0.03%
Common Stock | First ATM Program | Cowen
Common Stock
Aggregate maximum offering amount	$ 10,000
Common Stock | Second ATM Program
Common Stock
Number of shares issued		5,390,255
Share price (in dollars per share)		$ 1.59
Additional common stock issued		$ 8,600
Net proceeds		$ 8,300

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