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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Operating activities    
Net loss $ (6,038) $ (7,652)
Reconciliation of net loss to net cash used in operating activities:    
Depreciation and amortization 8 62
Stock-based compensation expense 408 479
Accretion of discount/premium on investment securities 7  
Non-cash interest expense   20
Services received in non-monetary exchange 6  
Changes in assets and liabilities:    
Prepaid expenses and other current assets 354 205
Other assets (25)  
Right-of-use asset-operating 12  
Accounts payable 48 342
Accrued expenses (1,313) (277)
Other liabilities (54) 2
Net cash used in operating activities (6,587) (6,819)
Investing activities    
Purchases of short-term investments (47,015)  
Sales and maturities of short-term investments 29,277  
Net cash used in investing activities (17,738)  
Financing activities    
Proceeds from public offerings, net of issuance costs 18,635  
Proceeds from at-the-market offering, net of issuance costs 2,045 8,313
Proceeds from exercise of common stock options and warrants 3  
Payments on borrowing   (833)
Net cash provided by financing activities 20,683 7,480
Net (decrease) increase in cash, cash equivalents and restricted cash (3,642) 661
Cash, cash equivalents and restricted cash, beginning of period 15,407 16,482
Cash, cash equivalents and restricted cash, end of period 11,765 17,143
Supplemental disclosure of cash flow information    
Cash paid for interest   $ 42
Non-cash financing activities    
Public offering issuance costs included in accounts payable $ 130