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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Operating activities    
Net loss $ (13,169) $ (14,131)
Reconciliation of net loss to net cash used in operating activities:    
Depreciation and amortization 15 105
Stock-based compensation expense 849 924
Accretion of discount/premium on investment securities 15  
Non-cash interest expense   33
Gain on disposal of property and equipment   (148)
Services received in non-monetary exchange 10 5
Changes in assets and liabilities:    
Prepaid expenses and other current assets 456 641
Other assets (25)  
Right-of-use asset-operating (9)  
Accounts payable (160) (402)
Accrued expenses (256) 547
Other liabilities (51) 5
Net cash used in operating activities (12,325) (12,421)
Investing activities    
Purchases of short-term investments (88,506)  
Sales and maturities of short-term investments 74,277  
Proceeds from sale of property and equipment   8
Net cash (used in) provided by investing activities (14,229) 8
Financing activities    
Proceeds from public offerings, net of issuance costs 18,505 39,325
Proceeds from at-the-market offering, net of issuance costs 2,315 8,313
Proceeds from exercise of common stock options and warrants 55 4
Payments on borrowing   (1,667)
Net cash provided by financing activities 20,875 45,975
Net (decrease) increase in cash, cash equivalents and restricted cash (5,679) 33,562
Cash, cash equivalents and restricted cash, beginning of period 15,407 16,482
Cash, cash equivalents and restricted cash, end of period 9,728 50,044
Supplemental disclosure of cash flow information    
Cash paid for interest   68
Non-cash financing activities    
At-the-market issuance costs included in accounts payable and accrued expenses $ 141  
Public offering issuance costs included in accounts payable   $ 414