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Organization and Operations - Liquidity (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | --- | ---
Feb. 06, 2019 | Jul. 19, 2016 | Sep. 30, 2019 | Sep. 30, 2019 | Sep. 30, 2018 | Dec. 31, 2018
Common Stock |  |  |  |  |  |
Common stock, par value (in dollars per share) |  |  | $ 0.001 | $ 0.001 |  | $ 0.001
Accumulated deficit |  |  | $ (216,987) | $ (216,987) |  | $ (197,304)
Cash, cash equivalents and short-term investments |  |  | $ 40,600 | $ 40,600 |  |
Common stock |  |  |  |  |  |
Common Stock |  |  |  |  |  |
Number of shares issued |  |  | 161,349 | 564,590 | 539,026 |
Additional common stock issued |  |  |  | $ 1 | $ 1 |
Common stock | Cowen |  |  |  |  |  |
Common Stock |  |  |  |  |  |
Percentage of commission paid to underwriter based on proceeds from common stock |  | 3.00% |  |  |  |
Common stock | ATM |  |  |  |  |  |
Common Stock |  |  |  |  |  |
Number of shares issued |  |  |  | 564,590 |  |
Share price (in dollars per share) |  |  | $ 6.32 | $ 6.32 |  |
Net proceeds |  |  |  | $ 3,200 |  |
Common stock | First ATM Program | Cowen |  |  |  |  |  |
Common Stock |  |  |  |  |  |
Remaining current sales agreement |  | $ 48,500 |  |  |  |
Common stock | February 2019 Financing | Oppenheimer & Co. Inc |  |  |  |  |  |
Common Stock |  |  |  |  |  |
Number of shares issued | 4,000,000 |  |  |  |  |
Number of warrants issued | 2,000,000 |  |  |  |  |
Warrants price (in dollars per unit) | $ 5.00 |  |  |  |  |
Proceeds from public offering, net of issuance costs | $ 18,500 |  |  |  |  |

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