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Organization and Operations - Liquidity (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | ---
Jan. 30, 2020 | Feb. 06, 2019 | Jun. 19, 2018 | Jul. 19, 2016 | Jan. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Stockholders' Equity |  |  |  |  |  |  |
Gross proceeds from public offering |  |  |  |  |  | $ 6,996 | $ 8,363
Accumulated deficit |  |  |  |  |  | (223,597) | $ (197,304)
Cash, cash equivalents and short-term investments |  |  |  |  |  | $ 36,200 |
Common stock |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Number of shares issued |  |  |  |  |  | 1,282,904 | 577,195
Gross proceeds from public offering |  |  |  |  |  | $ 1 | $ 1
Common stock | Cowen |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Percentage of commission paid to underwriter based on proceeds from common stock |  |  |  | 3.00% |  |  |
Common stock | ATM |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Number of shares issued |  |  |  |  |  | 1,282,904 |
Share price (in dollars per share) |  |  |  |  |  | $ 5.81 |
Gross proceeds from public offering |  |  |  |  |  | $ 7,500 |
Proceeds from public offering, net of issuance costs |  |  |  |  |  | $ 7,000 |
Common stock | First ATM Program | Cowen |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Remaining available under sales agreement |  |  |  | $ 43,600 |  |  |
Common stock | February 2019 Financing | Oppenheimer & Co. Inc |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Number of shares issued |  | 4,000,000 | 4,200,000 |  |  |  |
Share price (in dollars per share) |  |  | $ 0.001 |  |  |  |
Number of warrants issued |  | 2,000,000 | 4,200,000 |  |  |  |
Warrants price (in dollars per unit) |  | $ 5.00 | $ 10.00 |  |  |  |
Gross proceeds from public offering |  |  | $ 42,000 |  |  |  |
Proceeds from public offering, net of issuance costs |  | $ 18,500 | $ 38,900 |  |  |  |
Common stock | January 2020 Financing | Oppenheimer & Co. Inc |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Share price (in dollars per share) | $ 5.00 |  |  |  |  |  |
Gross proceeds from public offering | $ 26,500 |  |  |  |  |  |
Subsequent Events | ATM |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Number of shares issued |  |  |  |  | 173,572 |  |
Share price (in dollars per share) |  |  |  |  | $ 6.29 |  |
Gross proceeds from public offering |  |  |  |  | $ 1,100 |  |
Subsequent Events | 2020 Equity financings |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Proceeds from public offering, net of issuance costs |  |  |  |  | $ 25,600 |  |
Subsequent Events | Common stock | Over-Allotment option for underwriters | Oppenheimer & Co. Inc |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Number of shares issued | 690,000 |  |  |  |  |  |
Subsequent Events | Common stock | January 2020 Financing | Oppenheimer & Co. Inc |  |  |  |  |  |  |
Stockholders' Equity |  |  |  |  |  |  |
Number of shares issued | 5,290,000 |  |  |  |  |  |
Proceeds from public offering, net of issuance costs | $ 24,500 |  |  |  |  |  |

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