XML 52 R29.htm IDEA: XBRL DOCUMENT
v3.22.0.1

Stock Incentive Plans (Tables) | 12 Months Ended
--- | ---
Dec. 31, 2021
Stock Incentive Plans |
Summary of stock option activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | Weighted | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | Average | ​ | ​ | ​
​ | ​ | ​ | ​ | Weighted- | ​ | Remaining | ​ | Aggregate
​ | ​ | ​ | ​ | Average Exercise | ​ | Contractual | ​ | Intrinsic Value
​ |  | Shares |  | Price |  | Term (years) |  | (in thousands)
Outstanding at December 31, 2020 | ​ | 227,846 | ​ | $ | 68.25 | ​ | 8.13 | ​ | $ | —
Granted |  | 1,156,646 | ​ | $ | 15.91 | ​ | ​ | ​ | ​ | ​
Assumed in Quellis Acquisition | ​ | 55,414 | ​ | $ | 1.73 | ​ | ​ | ​ | ​ | ​
Exercised | ​ | (10,470) | ​ | $ | 2.10 | ​ | ​ | ​ | ​ | ​
Cancelled or forfeited |  | (81,196) | ​ | $ | 48.13 | ​ | ​ | ​ | ​ | ​
Expired | ​ | (1,507) | ​ | $ | 100.85 | ​ | ​ | ​ | ​ | ​
Outstanding at December 31, 2021 |  | 1,346,733 | ​ | $ | 22.25 |  | 9.02 | ​ | $ | 168,181
Vested and exercisable at December 31, 2021 |  | 135,412 | ​ | $ | 72.76 |  | 7.19 | ​ | $ | 77,798
​
Schedule of assumptions made based on the Black-Scholes option pricing model | ​
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year Ended December 31, | ​
​ |  | 2021 |  | 2020 | ​
Weighted-average expected volatility |  | 69.28-71.32% | ​ | 75.51-82.08% | ​
Expected term (in years) |  | 5-6.25 | ​ | 5.50-6.25 | ​
Risk-free interest rate |  | 0.42-1.36% | ​ | 0.37-1.51% | ​
Expected dividend yield |  | 0% | ​ | 0% | ​
​

X
- References No definition available. + Details
Name: | us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
Name: | us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration

X
- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
Name: | us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | dtr-types:textBlockItemType
Balance Type: | na
Period Type: | duration