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Income Taxes - Deferred tax assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets
Net operating loss carryforwards	$ 75,849	$ 65,373
Tax credit carryforwards	10,063	9,273
Capitalized research and development	139	482
Capitalized legal expenses	1,048	1,070
Lease liability	99	284
Other differences	1,977	1,648
Total deferred tax assets	89,175	78,130
Deferred tax liabilities
ROU asset	(107)	(262)
Valuation allowance	(89,068)	(77,868)
Net deferred tax assets	0	0
Increase in valuation allowance	$ 11,200	$ 11,100

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